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维生素C对慢性阻塞性肺疾病急性加重患者氧化应激及肺功能的影响 被引量:2

Effect of Vitamin C on Oxidative Stress and Lung Function of Patients with Acute Exacerbation Chronic Obstructive Pulmonary Diseases
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摘要 目的分析维生素C对慢性阻塞性肺疾病急性加重患者氧化应激及肺功能的影响。方法方便选择该院2015年2月—2016年8月收治的慢性阻塞性肺疾病急性加重期患者74例为研究对象,依入院顺序分为两组,各37例。两组患者入院后均接受慢阻肺临床常规治疗,观察组在此基础上服用维生素C。将两组患者治疗前后氧化应激和肺功能进行对比。结果治疗后两组血清GSH、SOD水平均有提高,MDA水平均有下降,治疗后观察组血清GSH、SOD、MDA分别为(16.86±1.54)U/L、(131.96±5.45)U/m L、(23.29±3.87)nmol/m L,优于对照组的(12.82±1.30)U/L、(117.98±7.61)U/m L、(26.21±4.20)nmol/m L,差异有统计学意义(P<0.05);治疗后观察组FEV1%pre、呼吸困难评分改善幅度均优于对照组,差异有统计学意义(P<0.05)。结论慢性阻塞性肺疾病急性加重期患者服用维生素C可缓解氧化应激程度,优化肺功能。 Objective To analyze the effect of vitamin C on oxidative stress and lung function of patients with acute exacerbation chronic obstructive pulmonary diseases. Methods 74 cases of patients with acute exacerbation chronic obstructive pulmonary diseases admitted and treated in our hospital from February 2015 to August 2016 were convenient selected as the research objects according to the admission order with 37 cases in each, both groups adopted the routine treatment, the observation group adopted the vitamin C, and the oxidative stress and lung function before and after treatment were compared between the two groups. Results After treatment, the serum GSH and SOD level of the two groups increased, and the MDA level decreased, and after treatment, the serum GSH, SOD and MDA in the observation group were better than those in the control group[(16.86±1.54)U/L,(131.96±5.45)U/m L,(23.29±3.87)nmol/m L vs(12.82±1.30)U/L,(117.98±7.61)U/m L,(26.21±4.20)nmol/m L], and the differences had statistical significance(P〈0.05), after treatment, the FEV1%pre and dyspnea score improvement range in the observation group were better than those in the control group, and the differences had statistical significance(P〈0.05). Conclusion Vitamin C for patients with acute exacerbation chronic obstructive pulmonary diseases can relieve the oxidative stress degree and optimize the lung function.
作者 钟兴峰
出处 《中外医疗》 2017年第6期113-114,117,共3页 China & Foreign Medical Treatment
关键词 慢性阻塞性肺疾病 维生素C 氧化应激 肺功能 Chronic obstructive pulmonary diseases Vitamin C Oxidative stress Lung function
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