期刊文献+

胰岛素强化治疗非增生期糖尿病视网膜病变对视网膜中谷氨酸表达的影响 被引量:5

Effects of intensive insulin therapy on expression of glutamic acid in retina of non-proliferative diabetic retinopathy
下载PDF
导出
摘要 目的探讨胰岛素强化治疗非增生期糖尿病视网膜病变对视网膜中谷氨酸表达的影响。方法采用前瞻性研究方法,选取2013年8月至2015年12月在该院诊治的非增生期糖尿病视网膜病变患者104例,根据入院顺序分为观察组与对照组各52例。对照组采用常规治疗,在降糖方面给予降糖药物口服治疗;观察组在降糖方面给予胰岛素强化治疗,其他治疗同对照组,2组都治疗观察4周。结果观察组与对照组的总有效率分别为98.1%和86.5%,观察组的总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后2组的胰岛素抵抗指数(HOMA-IR)显著降低,而胰岛素分泌指数(HOMA-IS)显著升高,差异有统计学意义(P<0.05),治疗后观察组的HOMA-IR、HOMA-IS与对照组比较差异有统计学意义(P<0.05)。观察组与对照组治疗后的患眼舒张末期血流速度(EDV)与收缩期峰值血流速度(PSV)值都显著高于治疗前,差异有统计学意义(P<0.05);同时观察组治疗后的患眼EDV与PSV值也显著高于对照组,差异有统计学意义(P<0.05)。观察组与对照组治疗后的谷氨酸水平分别为(3.20±1.34)和(5.38±1.24)μmol/L,都显著低于治疗前的(11.38±2.18)和(11.99±1.83)μmol/L,治疗后观察组的谷氨酸水平显著少于对照组,差异有统计学意义(P<0.05)。结论胰岛素强化治疗非增生期糖尿病视网膜病变能减少视网膜中谷氨酸的表达,降低胰岛素抵抗,促进基础胰岛素分泌,有利于改善患者的视神经状况,从而促进患者视力的恢复。 Objective To investigate the effects of intensive insulin therapy on the expression of glutamic acid in the retina of non-proliferative diabetic retinopathy.Methods The prospective study method was adopted,104 cases of non-proliferative stage of diabetic retinopathy in our hospital from August 2013 to December 2015 were selected and divided into the observation group and control group accorded to the order of admission,52 cases in each group.The control group was treated with routine treatment and given the oral hypoglycemic drug treatment,while the observation group was given the insulin intensive therapy in reducing glucose and other treatment was the same as that of the control group.Then the treatment in the two groups was observed for 4weeks.Results The total effective rates of the observation group and control group were 98.1%and 86.5%respectively,and the total effective rate of the observation group was significantly higher than that of the control group with statistical difference(P〈0.05).HOMA-IR after treatment in the two groups was significantly decreased,while HOMA-IS was significantly elevated,the differences were statistically significant(P〈0.05),and HOMA-IR and HOMA-IS after treatment had statistical difference between the observation group and control group(P〈0.05).The affected eye EDV and PSV values after treatment in the observation group and control group were significantly higher than those before treatment with statistical difference(P〈0.05),meanwhile the affected eye PSV and EDV values after treatment in the observation group were also significantly higher than those in the control group with statistical difference(P〈0.05).The glutamic acid levels after treatment in the observation group and control group were(3.20±1.34)and(5.38±1.24)μmol/L,which were significantly lower than(11.38±2.18)and(11.99±1.83)μmol/L before treatment,the glutamic acid level after treatment in the observation group was significantly lower than that in the control group,the difference was statistically significant(P〈0.05).Conclusion The intensive insulin treatment for treating non-proliferative diabetic retinopathy can reduce the expression of retinal glutamic acid and reduces the insulin resistance,promotes the secretion of insulin and is conducive to improve the patient′s visual nerve status,thus to promote the recovery of visual acuity.
作者 王哲
出处 《检验医学与临床》 CAS 2017年第8期1098-1100,1103,共4页 Laboratory Medicine and Clinic
关键词 胰岛素强化治疗 非增生期糖尿病视网膜病变 谷氨酸 视神经 视力 intensive insulin therapy non-proliferative diabetic retinopathy glutamic acid optic nerve visual acuity
  • 相关文献

参考文献12

二级参考文献120

共引文献87

同被引文献51

引证文献5

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部