不同浓度肝素封管液对糖尿病患者静脉留置针封管效果的研究

Effect of different concentrations of heparin-encapsulated liquid on intravenous indwelling needle sealing in diabetic patients

目的探索3种不同浓度肝素封管液对糖尿病患者静脉留置针的封管效果。方法选取2009年6月~2012年5月我院收治的90例糖尿病患者,将患者动态随机化分为三组,每组30例,A组采用125 U/ml肝素5 ml封管,B组采用100 U/ml肝素5 ml封管,C组采用150 U/ml肝素5 ml封管,比较三组患者的反复穿刺、封管后再通情况、纤维蛋白水平、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)。结果 B组患者的反复穿刺率(3.33%)低于A组(20.00%)及C组(33.33%),封管后再通率(93.33%)高于A组(66.67%)及C组(50.00%),差异有统计学意义(P<0.05)。B组患者Fg水平、APTT、PT明显优于A组及C组,差异有统计学意义(P<0.05)。结论 100 U/ml肝素封管液浓度为5 ml(管内浓度500 U)封管效果最为显著,将其用于糖尿病患者静脉留置针中,可降低堵塞率。

Objective To explore the effect of three different concentrations of heparin sealant on intravenous indwelling needle sealing in diabetic patients.Methods 90 Patients with diabetes mellitus in our hospital from June 2009 to May 2012 were selected and randomly divided into three groups,with 30 patients in each group.Group A used 125 U/ml heparin sealant 5 ml,group B used 100 U/ml heparin sealant 5 ml,and group C used 150 U/ml heparin sealant 5 ml.The incidence of repeated puncture and patency after sealing,the level of fibrin,APTT and PT were compared between two group.Results The incidence of repeated puncture in group B （3.33%） was lower than that in group A （20.00%） and C （33.33%）,the incidence of patency after sealing in group B （93.33%） was higher than that in group A （66.67%） and C （50.00%）,and the differences were statistically significant （P〈0.05）.The level of fibrin,AtrgF and PT of group B was better than that in group A and C,and the differences were statistically significant （P〈0.05）.Conclusion Heparin sealed liquid concentration of 5 ml 100 U/ml （tube concentration 500 U） with the most effective sealing effect, it will be used in patients with diabetes intravenous indwelling needle, can reduce the blocking rate.