重度子痫前期患者术后应用硫酸镁及乌拉地尔的临床观察

Clinical observation on treatment of severe preeclampsia after cesarean delivery by magnesium sulfate and urapidil

目的观察硫酸镁、乌拉地尔对重度子痫前期剖宫产术后患者降压治疗中的作用。方法对我院产科重症病房收治的106例重度子痫前期剖宫产术后患者进行随机分组,对照组为单用乌拉地尔组,试验组为硫酸镁+乌拉地尔组,两组均对用药后3h血压进行评价,对两组的ICU住院天数、乌拉地尔泵入总量及72h阴道出血量进行比较。结果对照组和试验组的降压满意率显示出统计学差异(P<0.05),两组的ICU住院天数、乌拉地尔泵入总量及72h阴道出血量未显示出统计学差异(P>0.05)。结论乌拉地尔在治疗子痫前期剖宫产术后患者过程中显示出了良好的降压效果,且硫酸镁的解痉治疗在本研究中显示出与乌拉地尔降压的协同作用。

Objective：To observe the clinical effect of magnesium sulfate and urapidil in treating severe preeclampsia after cesarean delivery. Methods：106 severe preeclampsia patients which were treated in our intensive care unit were randomly divided into the observation group and the control group.the control group used urapidil alone,the observation group used magnesium sulfate and urapidil,measured the blood pressure after used drags 3hours later,we compared the observation group with the control group on number of days in ICU,dosage of urapidil and amount of 72 hours bleeding after cesarean delivery. Results：Satisfaction rate of depressurization show statistical difference（P〈0.05）.compared with control group,number of days in ICU,dosage of urapidil and amount of 72 hours bleeding after cesarean delivery in observational group even did not show statistical difference（P〉0.05）. Conclusion：Urapidil has significant depressurization effect in severe preeclampsia patients after cesarean delivery,and magnesium sulfate has synergistic effect with urapidil on controlling blood pressure in this study.