疏肝柴胡散对胆囊切除术后综合征的临床疗效及安全性

Clinical efficacy and safety of chaihu shugan powder in the treatment of post-cholecystectomy syndrome

目的:探讨疏肝柴胡散联合胆舒胶囊和消炎利胆片对胆囊切除术后综合征的临床疗效及安全性。方法:将90例胆囊切除术后综合征患者按随机数字表法分为对照组(45例)和试验组(45例),对照组给予胆舒胶囊2粒/次,3次/d,和消炎利胆片6片/次,3次/d,试验组在对照组治疗基础上给予疏肝柴胡散口服治疗,1剂/d。治疗1月后观察两组患者的临床疗效,腹痛、腹胀、纳差、恶心等临床症状和不良反应,采用焦虑自评量表评价(SAS)和自评抑郁量表(SDS)评价患者的不良情绪。结果:试验组总有效率为97.78%(44/45),高于对照组的77.78%(35/45)(P<0.05)。试验组的腹痛、腹胀、纳差、恶心积分分别为(0.94±0.52)、(0.86±0.45)、(0.73±0.47)、(0.72±0.41)分,显著低于对照组的(2.62±0.51)、(1.71±0.43)、(1.51±0.52)、(1.41±0.45)分(P<0.05)。试验组的不良情绪SAS评分和SDS评分分别为(42.64±7.35)、(32.37±7.09)分,显著低于对照组的(50.31±8.62)、(48.41±7.11)分(P<0.05)。两组患者均未见明显不良反应。结论:疏肝柴胡散联合胆舒胶囊和消炎利胆片治疗胆囊切除术后综合征具有较好的临床疗效,可改善患者临床症状,提高患者治疗积极性,且无不良反应,值得临床推广应用。

AIM：To evaluate the clinical efficacy and safety of chaihu shugan powder combined with danshu capsule and xiaoyan lidan tablet in the treatment of post-cholecystectomy syndrome.METHODS：Ninety patients with post-cholecystectomy syndrome were divided into control group （45 cases） and treatment group （45 cases） according to random number table method.The control group was given danshu capsule,2 capsules/time,3 times/d,and xiaoyan lidan tablet,6 pills/time,3 times/d,and the control group was given chaihu shugan powder,1 dose/d,on the basis of control group.After one month therapy,the clinical efficacy,clinical symptoms such as abdominal pain,abdominal distention,anepithymia,nausea and adverse reactions were observed in two groups,and self-rating anxiety scale （SAS） and self-rating depression scale （SDS） were used to evaluate the patient＇s bad mood.RESULTS：The total effective rate 97.78% （44/45） in treatment group was higher than that of the control group 77.78% （35/45） （P 〈0.05）.The scores of abdominal pain （0.94 ± 0.52）,abdominal distension （0.86 ± 0.45）,anepithymia （0.73 ± 0.47） and nausea（0.72 ±0.41）in treatment group were significantly lower than the control group （2.62 ± 0.51）,（1.71 ±0.43）,（1.51 ±0.52） and（1.41 ±0.45） （P 〈 0.05）.The scores of SAS （42.64 ± 7.35） and SDS（32.37 ± 7.09） in treatment group were significantly lower than the control group （50.31 ± 8.62） and （48.41 ±7.11）（P〈0.05）.No obvious adverse reactions were found in two groups.CONCLUSION：Chaihu shugan powder combined with danshu capsule and xiaoyan lidan tablet in the treatment of post-cholecystectomy syndrome have better clinical curative effect,can improve clinical symptoms,increase patients＇ enthusiasm and bad no adverse reactions.It was worthy of clinical popularization and application.