小牛血清去蛋白注射液辅助治疗缺血性脑卒中临床疗效观察

Observationon of Clinical Effect of Deproteinised Calf Blood Serum Injection in the Adjuvant Treatment of Ischemic Stroke

目的:观察小牛血清去蛋白注射液辅助治疗缺血性脑卒中的临床疗效。方法:186例缺血性脑卒中患者随机分为试验组和对照组各93例。对照组给予常规治疗;试验组在对照组治疗基础上加用小牛血清去蛋白注射液。两组疗程均为4周。观察两组临床疗效及并发症发生情况,比较两组患者治疗前后血液流变学指标(全血黏度、血浆黏度、血小板聚集率)和神经功能缺损评分(NIHSS)的变化情况。结果:试验组总有效率为88.17%,显著高于对照组的69.89%(P<0.05)。试验组并发症发生率为8.60%,明显低于对照组的22.58%(P<0.05)。治疗后两组患者的全血黏度、血浆黏度、血小板聚集率等指标和NIHSS评分均较治疗前明显改善(P<0.05);且试验组各项指标均明显优于对照组(P<0.05)。结论:小牛血清去蛋白注射液辅助治疗缺血性脑卒中疗效显著,能有效改善患者的神经功能损伤和血液流变学各项指标,减少并发症的发生,值得临床推广。

Objective： To observe the clinical effect of ischemic stroke treated with the aid of deproteinized calf serum injection. Methods： 186 patients with ischemic stroke were randomly divided into experimental group and control group （ n = 93 ）. The control group was given conventional treatment, and the experimental group was added with deproteinised calf serum albumin injection on the basis of the control group. The course of treatment was 4 weeks. The clinical effect and complications of the two groups were observed, the changes of hemorheology indexes （ blood viscosity, plasma viscosity, platelet aggregation） and neurological deficit score （NIHSS score） were compared between the two groups before and after treatment. Results：The total effective rate of the experimental group was 88.17%, which was significantly higher than the control group 69.89% （P 〈0.05） ; the incidence of complications in the experimental group was 8.60%, which was sig- nificantly lower than the control group 22.58% （P 〈 0.05）. After treatment, the blood viscosity, plasma viscosity, blood cell aggregation index and NIHSS score were significantly improved in the two groups than before （ P 〈 0.05 ） ; and each index of the experimental group was significantly better than the control group （ P 〈 0.05 ）. Conclusion： The effect of deproteinized calf blood injection in the treatment of ischemic stroke was remarkable, which could effectively improve the nerve function damage and hemorheology indexes of patients, reduce the occurrence of complications, and was worthy of clinical promotion.