关节镜联合康复支具对骨性关节炎患者膝关节功能及炎性因子的影响

Clinical Effect of Arthroscopy Combined with Rehabilitation Brace on Osteoarthritis and Its Influence on Inflammatory Factors

目的:分析关节镜联合康复支具治疗骨性关节炎的临床疗效及对炎性因子影响。方法:选择我院收治的90例骨性关节炎患者作为研究对象,随机分为治疗组和对照组,每组45例。治疗组采用关节镜联合康复支具治疗,对照组采用单独关节镜治疗。比较两组患者的临床疗效、VAS疼痛评分、Lysholm膝关节功能评分,以及血清炎性因子的变化情况。结果:治疗组VAS评分变化优良率显著高于对照组,比较有统计学意义(X2=5.79,P<0.05);两组患者治疗后Lysholm膝关节功能评分较治疗前上升,且治疗组显著高于对照组,比较有统计学意义(t=6.8051,P<0.05);两组患者治疗后血清炎性因子CRP、IL-1β、MMP-3、IL-6较治疗前均有所下降,且治疗组低于对照组,比较具有统计学意义(P<0.05)。结论:关节镜联合康复支具治疗骨性关节炎临床疗效显著,可有效促进患者膝关节功能恢复,改善患者疼痛等临床症状,抑制血清炎性因子的表达。

Objective： To analyze the clinical effect of arthroscopy combined with rehabilitation brace on osteoarthritis and its influence on inflammatory factors. Methods： 90 patients with osteoarthritis who were treated in our hospital were randomly divided into treatment group （n = 45） and control group （n = 45）. The patients in the treatment group were treated with arthroscopy and rehabilitation support, while the patients in the control group were treated with arthroscopy. Then the clinical curative effect, the VAS and Lysholm knee fimction scores and the changes of serum inflammatory factors were observed and compared between the two groups. Results： The VAS score of the treatment group was significantly higher than that of the control group （χ2 = 5.79, P〈0.05）. The Lysholm knee function score of the two groups after the treatment were higher than before treatment, and the treatment group was significantly higher than that of the control group （T = 6.8051, P〈0.05）. The serum levels ofCRP, IL-113, MMP-3 and IL-6 in the two groups decreased after treatment, and the levels of CRP increased, and the treatment group was lower than that of the control group （P 〈0.05）. Conclusions： Arthroscopy combined with rehabilitation has better clinical effect on the treatment of osteoarthritis, which can effectively promote the recovery of knee functions and clinical symptoms, inhibite the serum levels of the inflammatory factors.