男性酒依赖患者客体、语音及空间工作记忆研究

Study on object, verbal and space working memory in male patients with alcohol dependence

目的探讨男性酒依赖患者工作记忆特点。方法将50例男性酒依赖患者及与其人口学资料相匹配的50例健康对照组分别测量比较两组被试数字广度测试、连线测试、词汇流畅性测试，并同时比较两组在客体、语音及空间工作记忆的差异。结果酒依赖患者组在客体、语音、空间工作记忆错误数[分别为（3．76±2．20）个，3（2，5）个，（3．74±2．40）个]均差于健康对照组[分别为（2．94±1．60）个，2（1，3）个，2（1，4）个]，差异有统计学意义[分别（t=2．133，P=0．035；Z=-2．400，P=0．016；z=-2．654，P=0．008）]，密西根酒精使用问卷得分与语音工作记忆错误数呈正相关（r=0．371，P=0．008）。结论男性酒依赖患者存在工作记忆功能全面的损害。

Objective To explore working memory in male patients with alcohol dependence. Methods 50 male patients with alcohol dependence （ AD group） and 50 healthy controls （ HC group） were assessed by digit span test, trail making test and verbal fluency test. The visual-object, visual-verbal, visual- space working memory tasks were used to measure the difference of working memory between the two groups. Results Compared with HC group, alcohol dependence group showed significant impairments in perform- ance of error number of visual-object, visual-verbal, visual-space working memory tasks （AD group： （3.76± 2.20） ,3（2,5）, （3.74±2.40）） ; （ HC group： （2.94±1.60） ,2（ 1,3） ,2（ 1,4） ） （ t= 2.133, P= 0.035; Z= -2.400, P= 0.016; Z=-2.654, P= 0.008）. Moreover, scores of Michigan alcoholism screening test were posi- tively correlated with the error number of verbal working memory task （ r=0.371, P=0.008）. Conclusion The male patients with alcohol dependence exhibit impairments in all aspects of working memory.