多巴胺配合多巴酚丁胺治疗小儿重症肺炎的效果及对细胞因子的影响

The effect of Dopamine and Dobutamine in the treatment of children with severe pneumonia and its effects on cytokines

目的分析多巴胺配合多巴酚丁胺对小儿重症肺炎的治疗效果及其对细胞因子的影响。方法随机抽取2015年1月~2016年3月在烟台芝罘医院接受治疗的94例重症肺炎患儿,按照随机双盲原则将患儿分为对照组和观察组,每组各47例。两组患儿均接受相同的常规治疗;在此基础上,给予观察组患儿多巴胺和多巴酚丁胺。比较两组患者临床效果以及细胞因子水平变化情况。结果治疗后,两组患儿白细胞介素(IL)-6、IL-8、可溶性细胞黏附因子-1、C反应蛋白以及肿瘤坏死因子-α水平比治疗前显著降低(P<0.05);观察组患儿各炎性细胞因子指标水平低于对照组(P<0.05)。观察组患儿各项临床症状及体征好转所用时间比对照组短(P<0.05)。观察组总有效率高于对照组(P<0.05)。结论多巴胺配合多巴酚丁胺可以降低患儿炎性细胞因子水平,治疗小儿重症肺炎效果明显。

Objective To analyze the effect of Dopamine combined with Dobutamine in the treatment of children with severe pneumonia. Methods From January 2015 to March 2016, 94 children with severe pneumonia treated in Yantai Zhifu Hospital were selected. According to the randomized double blinded principle, they were divided into control group and observation group, with 47 cases in each group. The children in the two groups were received the same con- ventional treatment, and the observation group was given to Dopamine and Dobutamine based on the conventional treat ment. The clinical effect and the inflammatory cytokine levels of the two groups were compared. Results After treatment, the levels of IL-6, IL-8, soluble cell adhesion molecule -1, C reactive protein and tumor necrosis factor alpha in the two groups were decreased （P 〈 0.05）; and the inflammatory cytokine levels in the observation group were lower than those in the control group （P 〈 0.05）. The time of symptoms and signs improved in the observation group was shorter than that in the control group （P 〈 0.05）. The total efficiency of the observation group was higher than that of the control group （P 〈 0.05）. Conclusion Dopamine combined with Dobutamine can reduce the of inflammatory eytokines levels, and improve the curative effect of children with severe pneumonia.