阿司匹林联合氯吡格雷治疗对急性缺血性脑卒中患者血小板聚集率的影响

Effects of Aspirin Combined with Clopidogrel on Platelet Aggregation rate in Patients with Acute Ischemic Stroke

目的观察阿司匹林联合氯吡格雷对急性缺血性脑卒中患者血小板聚集率的影响。方法对245例急性缺血性脑卒中患者应用阿司匹林联合氯吡格雷两周后,分别使用二磷酸腺苷(ADP)和花生四烯酸(AA)作为诱导剂测定治疗前后患者血小板的聚集率。结果与治疗前相比,无论以ADP还是AA作为诱导剂,急性缺血性脑卒中患者血小板聚集率出现了明显的降低,并且差异具有统计学意义(P<0.05),同时阿司匹林联合氯吡格雷治疗能够使29例阿司匹林非敏感患者中23例转为阿司匹林敏感(P<0.05)。结论阿司匹林联合氯吡格雷可以有效的降低急性缺血性脑卒中患者血小板聚集率,并且可以一定程度上改善患者阿司匹林抵抗。

Objective To observe the effect of aspirin combined with clopidogrel on platelet aggregation rate in patients with acute ischemie stroke. Methods Two hundred and twenty-two patients with acute ischemic stroke were treated with aspirin and clopidogrel for two weeks. Adenosine diphosphate （ADP） and arachidonic acid （AA）were used as inducers to measure platelet aggregation rate before and after treatment. Results Platelet aggregation rate was significantly lower in patients with acute ischemie stroke compared with those before treatment （ P 〈 0.05 ）, and the difference was statistically significant （ P 〈 0.05 ）, and aspirin combined with clopidogrel Gray＇ s treatment could convert 23 aspirin-sensitive patients to aspirin- sensitive, and the differences were statistically significant （P 〈 0. 05 ）. Conclusion Aspirin combined with clopidogrel can effectively reduce platelet aggregation rate in patients with acute ischemic stroke, and can improve aspirin resistance in some extent.