脑卒中后抑郁患者血清TSH含量与神经递质、神经营养状态及神经细胞凋亡的关系

Relationship of serum TSH levels with neurotransmitters,neurotrophic state and nerve cell apoptosis in patients with post-stroke depression

目的:研究脑卒中后抑郁(PSD)患者血清促甲状腺激素(TSH)含量与神经递质、神经营养状态及神经细胞凋亡的关系。方法:选择在我院就诊的缺血性脑卒中患者并根据发病后14天时的HAMD-17评分将入组患者分为脑卒中后抑郁组(PSD组)和脑卒中组(PS组)。检测血清中TSH、神经递质、营养细胞因子、细胞凋亡分子的含量。结果:PSD组血清中TSH、5-HT、NE、DA、BDNF、NGF的含量均显著低于PS组,Bax、FasL、Fas、Caspase-3的含量均显著高于PS组;PSD组中TSH降低患者血清中5-HT、NE、DA、BDNF、NGF的含量均显著低于TSH正常患者,Bax、FasL、Fas、Caspase-3的含量均显著高于TSH正常患者。结论:PSD患者血清中TSH含量的降低会影响神经递质、神经营养状态及神经细胞凋亡。

Objective：To study the relationship of serum thyroid-stimulating hormone（TSH）levels with neurotransmitters,neurotrophic state and nerve cell apoptosis in patients with post-stroke depression（PSD）.Methods：Patients with ischemic stroke who were treated in our hospital between June 2014 and October 2016 were selected,and according to the HAMD-17 score 14days after onset,the enrolled patients were divided into into the post-stroke depression group（PSD group）and stroke group（PS group）.The serum levels of TSH,neurotransmitters,neurotrophic cytokines and apoptotic molecules were detected.Results：Serum TSH,5-HT,NE,DA,BDNF and NGF levels of PSD group were significantly lower than those of PS group while Bax,FasL,Fas and Caspase-3levels were significantly higher than those of PS group;5-HT,NE,DA,BDNF and NGF levels of PSD group of patients with low TSH were significantly lower than those of PSD group of patients with normal TSH while Bax,FasL,Fas and Caspase-3levels were significantly higher than those of PSD group of patients with normal TSH.Conclusion：The decrease of serum TSH level in patients with PSD can affect neurotransmitters,neurotrophic state and nerve cell apoptosis.