肠道病毒71型衣壳蛋白的抗原表位及其单克隆抗体

Epitopes of enterovirus 71 capsid proteins and the monoclonal antibodies

肠道病毒71（EV71）是手足口病的主要致病原之一,可引发大部分重症病例和死亡病例,其衣壳蛋白VP1～VP4作为免疫原包含了能够诱导体液免疫（产生抗体）和细胞免疫的抗原表位.迄今为止已有多个免疫显性的线性或构象性B细胞抗原表位被确定,与之相关的单克隆抗体在EV71感染的早期诊断和单克隆抗体治疗方面也已显示一定程度的应用前景,同时也有少数T细胞抗原表位被确定.本文对上述研究情况进行综述.

Enterovirus 71 （EV71） is one of main pathogens for hand,foot and mouth disease that results in most severe and fatal cases.The capsid protein VP1-VP4 of EV71 contain epitopes inducing humoral （antibody production） and cellular immunity,respectively.So far,some immunodominant linear or conformation B cell epitopes in EV71 VP1-VP4 have been identified,and their respective monoclonal antibodies have shown the prospect in early diagnosis and immunotherapy of EV71 infection.At the same time,a few T cell epitopes in EV71 VP1-VP4 are also identified.The above-mentioncd research advances are summarized in this review.