布地奈德雾化吸入对小儿哮喘患者外周血炎症因子及肺功能的影响

Budesonide Inhalation on Children with Asthma and Peripheral Inflammatory Factors and Pulmonary Function Index

目的:分析雾化吸入布地奈德后小儿哮喘患者的外周血炎症因子及肺功能指标的变化情况临床。方法:将2015年1月至2016年2月间我院收治的100例小儿哮喘患者随机分为观察组和对照组,对照组采用常规方案干预,观察组在对照组基础上雾化吸入布地奈德;治疗前及治疗结束后一周时检查患儿外周血TNF-α、IL-8、IL-4、免疫球蛋白水平,记录FEV1、FVC、PEF%,并评价患儿临床症状。结果:治疗后两组患者症状评分均明显降低,且差异存在统计学意义(P<0.05),且治疗后观察组患者症状评分显著低于对照组(P<0.05);经治疗后两组患儿FVC、FEV1及PEF均明显改善,且差异存在统计学意义(P<0.05),治疗后观察组患儿FVC、FEV1及PEF显著高于对照组(P<0.05);经治疗后两组患儿外周血IL-4、TNF-α及IL-8水平均明显降低,且差异存在统计学意义(P<0.05),治疗后观察组患儿外周血IL-4、TNF-α及IL-8水平显著低于对照组(P<0.05);经治疗后IgA、IgE水平显著降低(P<0.05),IgG、IgM水平显著升高(P<0.05),且治疗后两组患儿外周血免疫球蛋白水平差异存在统计学意义(P<0.05)。结论:雾化吸入布地奈德较单纯常规治疗更能有效改善小儿哮喘患者外周血炎症因子水平,提高肺功能,具有较高的临床应用价值。

Objective： To analyze aerosol inhalation of budesonide in children with clinical changes in patients with asthma and peripheral inflammatory factors and pulmonary function index. Methods： 100 cases of children with asthma admitted in our hospital from January 2015 to February 2016 were randomly divided into observation group and control group,the control group with routine intervention,the observation group in the control group on the basis of budesonide inhalation; after a week before and at the end of treatment,TNF-α in peripheral blood and IL-8,IL-4,immune immunoglobulin levels in children with asthma,were detected FEV1,FVC,PEF% records,and to evaluate the clinical symptoms in children. Results： After treatment,the symptom scores of patients of two groups were significantly reduced,and the difference was statistical significance（ P〈0.05）; and symptom score of the patients in the observation group after treatment was significantly lower than the control group（ P〈0.05）; after treatment,FVC,FEV1 and PEF of two groups were significantly improved,and the difference was statistical significance（ P〈0.05）; after treatment,the observation group with FVC,FEV1 and PEF were significantly higher than those in the control group（ P〈0.05）; after treatment,peripheral blood IL-4,TNF-α and IL-8 level of two groups of children were decreased,and the difference is statistical significance（ P〈0.05）; peripheral blood IL-4,TNF-α and IL-8 level of the observation group with after treatment was significantly lower than the control group（ P〈0.05）; after treatment,IgA and IgE were decreased significantly（ P〈0.05）; IgG and IgM levels were significantly higher（ P〈0.05）,statistically significant differences between the two groups of children with peripheral blood immunoglobulin level and survival after treatment（ P〈0.05）. Conclusions： Budesonide can effectively improve the level of inflammatory factor in children with asthma in peripheral blood and improve lung function,it has high value in clinical application.