以彩超为基准观察中药外洗对下肢动脉粥样硬化的影响

Effect of TCM Lotion on Atherosclerosis in Lower Extremity of Stagnation of Collaterals due to Phlegm and Blood Stasis Pattern Based on Color Doppler Ultrasound

目的:探讨中药外洗治疗痰瘀阻络型患者下肢动脉粥样硬化疾病的影响。方法:收集北京市房山区中医医院门诊及住院患者中属痰瘀阻络型下肢动脉粥样硬化疾病127例,将其随机分为3组,分别为观察组42例、常规组43例和对照组42例,分别给予标准西药+中药外洗治疗、标准西药+温水外洗治疗和标准西药治疗,2周为1个疗程,中间间隔2 d,外洗治疗6个疗程。观察3组治疗前、后下肢动脉血管内径、内-中膜厚度、血流速度变化情况。结果:与治疗前比较,治疗后3组下肢股总、股浅、腘动脉3根血管内径均明显增加,中-内膜厚度明显降低,血流速度明显增大,差异均有统计学意义(P<0.05);治疗后组间两两比较,观察组明显优于常规组,常规组明显优于对照组,差异均有统计学意义(P<0.05)。治疗前后3组患者没有肝肾功能异常和其他不良反应发生。结论:中药外洗及温水浴足对下肢动脉粥样硬化疾病有改善作用,具有一定的的临床应用价值。

Objective ： To explore the effect of TCM loction for the treatment of atherosclerotic disease in lower extremity of stagna- tion of collaterals due to phlegm and blood stasis pattern. Methods： A total number of 127 c atherosclerotic disease in lower ex- tremity of stagnation of eollaterals due to phlegm and blood stasis pattern in outpatient and inpatient were collected and randomly divided into three groups ： treatment group （ n = 42 ）, conventional group （ n = 43 ） and control group （ n = 42 ）. Patients in the treatment group were given with western medicine and TCM wash lotion, patients in the conventional group with western medicine and warm water washing and patients in the control group simply with western medicine. Two weeks were set as a course of treat- ment for 6 courses with 2-day interval between each course. The changes of arterial diameter, intima-media thickness and blood flow velocity were observed before and after treatment. Results： The diameter of the common, superior femoral artery and deep femoral artery of the lower limbs of the three groups were significantly increased, the thickness of the medial-intima was significant- ly decreased and the blood flow velocity was significantly increased after the treatment, which the difference was statistically signifi- cant （ P 〈 0. 05 ）. The treatment group was significantly superior to the conventional group and the conventional group was signifi- cantly better than the control group, showing that the difference was statistically significant （P 〈 0. 05 ）. There were no liver and kidney dysfunction and other adverse reaction in the three groups before and after treatment. Conclusion： The TCM lotion and foot bath with warm water have the effect of improving atherosclerotic disease in lower extremity, with certain clinical application value.