吸烟与糖代谢异常关系研究进展

Advances in researches on relationship between cigarette smoking and abnormal glucose metabolism

目的中国人群吸烟率和糖尿病患病率居高不下,近年来许多流行病学研究也表明吸烟是糖尿病发生发展的独立危险因素;在吸烟与糖代谢异常关系的机制领域,越来越多的研究表明吸烟或香烟提取物可导致胰岛素抵抗和或胰岛细胞损伤,但大多停留在动物水平,细胞分子机制的研究仍较少。为此本文从流行病学和病理生理2个领域探讨吸烟与糖代谢异常的关系,旨在为糖尿病的防治提供理论依据。

The prevalence of cigarette smoking and diabetes are extremely high in China.Recently,many epidemiologic studies have shown that cigarette smoking is an independent risk factor for the development of diabetes.For the relationship between smoking and abnormal glucose metabolism,studies have proved that cigarette smoking and cigarette extract can cause insulin resistance or pancreatic beta-cell damage in vivo and in vitro,but the most of the results are from animal studies and a few of the studies were involved in molecular mechanisms of the effects.The study reviews published epidemiologic and pathophysiologic researches on the association of cigarette smoking with abnormal glucose metabolism for providing a theroretical basis for prevention and treatment of diabetes.