凋亡相关基因突变与人类疾病

Mutations of apoptosis genes in human diseases

细胞凋亡 (又称细胞程序性死亡 )过程由多种不同基因产物的协同作用来完成。其中某些凋亡基因的突变 ,已被认定为人类疾病的病因或相关因素。作者综述了当前对凋亡基因突变所致人类疾病的认识 。

Cell death by apoptosis is exerted by the coordinated action of many different gene products.Mutations in some of them,acting at different levels in the apoptosis process,have been identified as cause or contributing factor for human diseases.This article reviews the current knowledge on mutations of apoptosis genes involved in the pathogenesis and summarizes the gradual transformation of discoveries in apoptosis research into benefits for the clinical management of diseases.