美沙拉嗪口服联合栓剂治疗左半溃疡性结肠炎的效果评价

The Evaluation of Mesalamine Oral Combined with Suppository in Treatment of Left-sided Ulcerative Colitis Effect

目的探究美沙拉嗪口服联合栓剂治疗左半溃疡性结肠炎的效果评价。方法选取该院2013年1月—2015年12月共收治628例左半溃疡性结肠炎,随机分为观察组300例,对照组328例,均给予美沙拉嗪肠溶片,观察组在对照组的基础之上给予美沙拉嗪栓剂,比较两组的总有效率及不良反应发生率。结果观察组使用美沙拉嗪口服联合栓剂治疗的有效率为86.00%明显高于对照组的64.63%,差异有统计学意义(P<0.05);观察组不良反应发生率6.67%与对照组6.40%比较差异无统计学意义(P>0.05)。结论美沙拉嗪口服联合栓剂治疗左半溃疡性结肠炎与单纯美沙拉嗪口服治疗相比,可以增加肠道局部的药物浓度,提高疗效,不良反应率也并没有增加,值得在临床中推广。

Objective Research on the evaluation of Mesalamine oral combined with suppository in treatment of leftsided ulcerative colitis effect. Methods A total of 628 cases of left-sided ulcerative colitis were selected from January2013 to December 2015 in the hospital.Randomly divided into observation group 300 cases, 328 cases in the control group,both of them was given the Mesalamine Slow Release Tablets.Based on the observation group, the control group was given the Mesalamine suppository.The total effective rate and adverse reaction rate of the two groups were compared. Results The efficiency of the observation group 86.00% was higher than that of the control group 64.63%, the difference was statistically significant（P〈0.05）;There was no significant difference in the incidence of adverse reactions between the observation group 6.67% and the control group 6.40%（P〉0.05）. Conclusion Compared to mesalazine oral combined with suppository in the treatment of eft-sided ulcerative colitis with simple mesalazine oral treatment can increase the drug concentration at the local intestinal and improve the curative effect, adverse reaction rate did not increase, it is worth in clinical promotion.