炎琥宁联合利巴韦林治疗小儿病毒性肺炎的疗效及对炎症因子的影响

Curative effect of potassium sodium dehydroandroan drographolide succinate combined with ribavirin on the infantile viral pneumonia and its influence on inflammatory factors

目的探究炎琥宁联合利巴韦林治疗小儿病毒性肺炎的疗效及对炎症因子的影响。方法选取我院2015年1月~2017年4月间收治的180例小儿病毒性肺炎患儿为研究对象,根据随机数字表法将其分为实验组与对照组,每组90例,对照组患者予以利巴韦林治疗,实验组在此基础上予以炎琥宁治疗,观察统计两组患者的临床疗效、主要症状消失时间、不良反应、治疗前后血清中炎症因子肿瘤坏死因子(TNF)-α、白介素(IL)-6和IL-8水平变化。结果治疗前,两组患儿所有指标均无统计学差异(P>0.05);治疗后,实验组发热、咳嗽消失和肺部湿啰音吸收时间均显著短于对照组(P<0.05),实验组治疗总有效率(94.44%)显著高于对照组(84.44%)(P<0.05),且炎症因子TNF-α、IL-6和IL-8水平的改善程度显著优于对照组(P<0.05),两组患儿的不良反应发生率无统计学差异(P>0.05)。结论炎琥宁联合利巴韦林治疗小儿病毒性肺炎,可有效抑制炎症反应,改善感染症状,疗效显著,安全可靠。

Objective To explore the curative effect of Potassium Sodium Dehydroandroan Drographolide Suceinate combined with ribavirin on the infantile viral pneumonia and its influence on inflammatory factors. Methods 180 cases of infantile viral pneumonia in our hospital from January 2015 to April 2017 were selected as the research object, and according to the random number table method, they were divided into the experimental group and the control group, 90 cases in each group. The control group received the ribavirin treatment, and based on that, the experimental group received the Potassium Sodium Dehydroandroan Drographolide Succinate treatment. The clinical effect, the disappearance time of the cardinal symptom, adverse reactions, the serum inflammatory factor tumor necrosis factor （TNF） - α, the interleukin（IL） -6 and IL-8 level change of patients in two groups before and after the treatment were observed and statistically analyzed. Results Before the treatment, there were no significant differences of all patients indexes between the two groups （P 〉 0.05）. after the treatment, the fever, cough disappearance time and lung wet rales absorption time of the experimental group were significantly shorter than those of the control group （P 〈 0.05）, the total effective rate （94.44%） of the experimental group was significantly higher than the control group （84.44%） （P 〈 0.05）. And the level of tumor necrosis factor （TNF）- α, the interleukin（IL）-6 and IL-8 improved significantly better than the control group （P 〈 0.05）. The adverse reactions of the two groups had no significant difference （P 0.05）. Conclusion Potassium Sodium Dehydroandroan drographolide Succinate combined with ribavirin in the treatment of infantile viral pneumonia can effectively inhibit inflammation, improve the symptoms of infection, and it has obvious curative effect, which is safe and reliable.