甲状腺乳头状癌中央区及颈侧区淋巴结转移相关因素探讨

Correlative factors of lymph node metastasis in central region and cervical region of papillary thyroid carcinoma

甲状腺癌是内分泌系统最常见的恶性肿瘤,也是头颈部最常见的恶性肿瘤,近年来其发病率逐年增高。分化型甲状腺癌(DTC)占所有甲状腺癌的95%左右,其中,甲状腺乳头状癌(PTC)占DTC的90%以上。多数PTC生长较缓慢,但颈部淋巴结转移出现早。颈部淋巴结转移是甲状腺癌病人复发率增高和存活率降低的主要原因,因此,探讨淋巴结转移的危险因素非常重要。相关研究显示,癌灶直径、年龄、腺外侵犯、性别、BRAFV600E突变是PTC中央区及颈侧区淋巴结转移的危险因素。

Thyroid cancer is the most common malignant tumor of endocrine tumors. The incidence of thyroid cancer is increasing in recent years. Differentiated thyroid carcinoma （DTC） accounts for about 95% of all thyroid cancers, with papillary thyroid carcinoma （PTC） accounting for more than 90% of DTC. Most PTCs grew slowly, hut cervical lymph node metastasis occurred early. Neck lymph node metastasis is the main reasons for the high recurrence rate and low survival rate of thyroid cancer patients. Thereforel it is very important to expIore the risk factors of lymph nod~ metastasis. The article analyzed the risks of lymph nodes metastasis by reviewing the related literature. The results show that tumor diameter, age, gender, extrathyroid extension, BRAFV600E mutation are the risks factor for lymph node metastasis of lateral and central neck.