六味地黄丸联合二甲双胍治疗2型糖尿病肾阴亏虚的疗效研究

Clinical efficacy of Liuweidihuang Pill combined with Metformin in treatment of type 2 diabetes with Qi-Yin deficiency

目的探讨六味地黄丸联合二甲双胍治疗2型糖尿病肾阴亏虚的疗效。方法选取120例2型糖尿病肾阴亏虚患者,随机分为两组,对照组(60例)口服二甲双胍片0.5 g/次,3次/d,观察组在对照组治疗基础上,口服六味地黄丸大蜜丸1丸/次,2次/d。疗程均为4周。观察并记录两组临床疗效,治疗前后空腹血糖、餐后2 h血糖水平、治疗前后总症状积分以及治疗期间不良反应情况,以此评价六味地黄丸联合二甲双胍治疗2型糖尿病肾阴亏虚的疗效。结果观察组治疗有效率为88.3%,明显高于对照组的65.0%,差异有统计学意义(P<0.05)。治疗前两组患者空腹血糖和餐后2 h血糖水平相比,无统计学差异;治疗后两组空腹血糖和餐后2 h血糖水平均下降,组内差异有统计学意义(P<0.05);且观察组空腹血糖、餐后2 h血糖均低于对照组,组间差异有统计学意义(P<0.05)。治疗前,两组症状积分相比无统计学差异;治疗后两组总症状积分明显下降,组内差异有统计学意义(P<0.05);且观察组总症状积分低于对照组,组间差异有统计学意义(P<0.05)。治疗期间,对照组1例低血糖反应,观察组1例低血糖反应,1例轻度恶心,两组不良反应相比,无统计学差异。结论六味地黄丸联合二甲双胍对2型糖尿病具有较好的治疗效果,能明显改善糖尿病的临床症状,降糖作用明显,药品安全性高,值得临床推广使用。

Objective To discuss the efficacy of six ingredient rehmannia pill combined with metformin in treatment of type 2 diabetes with Qi-Yin deficiency. Methods 120 cases with type 2 diabetes were selected. They were divided into two groups randomly. The observation group （60 cases） took six ingredient rehmannia pill combined with metformin. The control group （60 cases） took metformin. The efficacy of interlocking intramedullary nail and fracture contusion capsule in treatment of open tibial fracutre was evaluated by fasting blood glucose, postprandial 2 h blood glucose, total symptom scores before and after treatment, adverse reaction during treatment. Results The effective rate of observation group was significantly higher than that of the control group （P 〈 0.05）. Before treatment, fasting blood glucose and postprandial 2 h blood glucose level had no significant difference between two groups. After treatment, the blood glucose of two groups were decreased （P 〈 0.05）. The fasting blood glucose and blood glucose 2 h after meal of observation group were lower than that of the control group （P 〈 0.05）. Before treatment, total symptom scores had no significant difference. After treatment, the two groups of the total symptom scores were decreased significantly （P 〈 0.05）, and the observation group the total symptom score lower than that of the control group （P 〈 0.05）. During the treatment, the control group of 1 cases of hypoglycemia, the observation group of 1 cases of hypoglycemia, 1 cases of mild nausea. The adverse reactions of two groups had no significant difference. Conclusion Six ingredient rehmannia pill combined with metformin had good effect on type 2 diabetes. It could significantly improve the symptoms of diabetes diagnosed by traditional Chinese medicine. The hypoglycemic effect was obvious with high drugy safety. It was worthy of clinical application.