轻度认知功能障碍患者失匹配负波的研究

Research on mismatch negativity wave in patients with mild cognitive impairment

目的探讨事件相关电位失匹配负波(MMN)对轻度认知功能障碍(MCI)的诊断价值。方法选取2015年4~9月在我院记忆门诊就诊的MCI患者(MCI组)24例,同期招募性别、年龄、文化程度基本匹配的正常老年人(NC组)21例,采用简易智力量表(MMSE)评价两组的认知功能,利用事件相关电位检查MCI患者和正常对照组人群的MMN进行比对及分析。结果 MCI组在Fz、Cz、Pz三电极点的MMN潜伏期和波幅与NC组差异无统计学意义(P>0.05)。结论 MCI患者的听觉MMN(AMMN)可能无明显异常。

Objective To explore the diagnostic value of event-related potential mismatch negativity （MMN） for mild cognitive impairment （MCI）.Methods From April to September in 2015,24 patients with MCI （MCI group） treated in our memory clinic were selected.At the same period,21 normal old people （NC group）with matched sex,age,and educational levels were recruited.The cognitive function in two groups was evaluated by mini-mental state examination （MMSE）. MMN was compared and analyzed in MCI patients and participants in normal control group by event-relatedexamina- tion.Results In MCI group,the latent period and amplitude of MMN in three electrode points of Fz,Cz,and Pz were not displayed statistical differences compared with the normal control group （P〉0.05）.Conclusion Auditory MMN （AMMN） in MCI patients may be not in significant abnormality.