MicroRNA-21的生理作用及其在缺血性心脏病中的研究进展被引量：5

Study of the physiological function of microRNA-21 and its application in ischemic heart disease

下载PDF

导出

摘要 MicroRNA(miRNA)是一类由22个左右核苷酸组成的高度保守的非编码小RNA分子,可通过抑制靶基因mRNA的翻译或通过促进mRNA降解对靶基因起到负性调控的作用。miRNA的生物功能复杂多样,与心脑血管疾病、肿瘤、血液系统疾病及肝脏疾病等也有密切关系。目前已发现数千种miRNA,miR-21是miRNA家族中的一员,参与心血管系统的多种生理及病理过程,近年来发现在缺血性心脏病中具有重要作用。本文就miR-21在缺血性心脏病的相关研究进展作一综述。 Composed of about 22 nucleotides,microRNA are a class of small,strongly conserved throughout evolution non-coding RNA molecules.MicroRNAs regulate gene expressions by suppressing the translation of the messenger RNA of target genes or by promoting mRNA degradation.The biological function of microRNA is complex and diverse,and has a close relationship with cardiovascular disease,tumor,blood system diseases and liver diseases and so on.Thousands of microRNA to been found,and microRNA-21 is a member of the microRNAs.MicroRNA-21 is involved in many physiological and pathological processes of cardiovascular system.In recent years,it has been found to play an important role in ischemic heart disease.This review article summarizes the research progress regarding the microRNA-21 and its relationship with myocardial ischemic heart disease.

作者刘杰赵玲琼胡厚祥

机构地区川北医学院附属医院心血管内科重庆医科大学附属第二医院肿瘤科

出处《西部医学》 2017年第11期1621-1625,共5页 Medical Journal of West China

基金国家自然科学基金青年科学基金资助项目(81600232)

关键词 MICRORNA MICRORNA-21 缺血缺氧心肌损伤缺血性心脏病 microRNA mieroRNA-21 Ischemia hypoxia Myocardial injury Ischemic heart disease

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献5

1陈伟伟,高润霖,刘力生,朱曼璐,王文,王拥军,吴兆苏,李惠君,郑哲,蒋立新,胡盛寿.《中国心血管病报告2014》概要[J].中国循环杂志,2015,30(7):617-622. 被引量：797
2唐艳,王梦洪.微小RNA-21对乳鼠心肌细胞凋亡及磷酸脂酶-张力蛋白同源物／丝氨酸／苏氨酸激酶／叉头蛋白3a信号传导通路的影响[J].中华心血管病杂志,2013,41(2):135-142. 被引量：15
3谢琼慧,赵超莉,叶子青,杨飞,阮琼芳,谢卫国.微小RNA-21对缺血缺氧大鼠心肌细胞凋亡的影响[J].中华烧伤杂志,2014,30(2):153-157. 被引量：4
4Li-Feng Liu,Zhuo Liang,Zhen-Rong Lv,Xiu-Hua Liu,Jing Bai,Jie Chen,Chen Chen,Yu Wang.MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury[J].Journal of Geriatric Cardiology,2012,9(1):28-32. 被引量：15
5陈伟伟,高润霖,刘力生,朱曼璐,王文,王拥军,吴兆苏,李惠君,顾东风,杨跃进,郑哲,蒋立新,胡盛寿.《中国心血管病报告2015》概要[J].中国循环杂志,2016,31(6):521-528. 被引量：948

二级参考文献59

1黄跃生.烧伤后早期心肌损害的分子机制及防治研究进展[J].中华烧伤杂志,2004,20(5):257-259. 被引量：29
2Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297.
3Yi R, Qin Y, Macara IG, et al. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 2003; 17: 3011-3016.
4Hutvagner G, Mclachlan J, Pasquinelli AE, et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2001; 293: 834-838.
5Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215-233.
6Valencia-Sanchez MA, Liu J, Hannon GJ, et al. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 2006; 20: 515-524.
7Small E M, Frost RJ, Olson EN. MicroRNAs add a new dimension to cardiovascular disease. Circulation 2010; 121: 1022-1032.
8Condorelli G, Latronico MV, Dorn GN. microRNAs in heart disease: putative novel therapeutic targets? Eur Heart J 2010; 31:649-658.
9Latronico MV, Catalucci D, Condorelli G. Emerging role of microRNAs in cardiovascular biology. Circ Res 2007; 101: 1225-1236.
10van Rooij E, Sutherland LB, Thatcher JE, et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 2008; 105: 13027-13032.