影响脂肪干细胞成脂分化的供体因素和实验因素研究进展

Research progress of the donor factors and experimental factors affecting adipogenic differentiation of adipose derived stem cells

目的总结影响脂肪干细胞成脂分化的供体因素和实验因素,为脂肪干细胞成脂分化研究提供参考。方法广泛查阅近年来国内外有关影响脂肪干细胞成脂分化的供体因素和实验因素相关研究报道,并进行总结。结果影响脂肪干细胞成脂分化的供体因素和实验因素很多,其中有很多因素仍存在争议,如供体年龄、健康状态、脂肪组织取材部位等,有待进一步研究。结论需进一步深入研究影响脂肪干细胞成脂分化的供体因素和实验因素,明确存在争议的事项,为脂肪干细胞在脂肪组织工程中的应用奠定基础。

Objective To summarize the donor factors and experimental factors that affect adipogenic differentiation of adipose derived stem cells, so as to provide reference for adipogenic differentiation of adipose derived stem cells. Methods The related research literature about donor factors and experimental factors affecting adipogenic differentiation of adipose derived stem cells in recent years was extensively reviewed and summarized. Results There are a lot of donor factors and experimental factors affecting adipogenic differentiation of adipose derived stem cells, but some of the factors are still controversial, such as donor age, health status, adipose tissue of different parts, and so on. These factors need to be further studied. Conclusion The donor factors and experimental factors that affect adipogenic differentiation of adipose derived stem cells should be deeply studied and the controversial issues should be clarified to lay a solid foundation for the application of adipose derived stem cells in adipose tissue engineering.