自噬与炎性反应之间分子联系的研究进展

Research progress in molecular connection between autophagy and inflammation

自噬是机体重要的代谢过程,参与细胞的多种应激反应如炎性反应。自噬与炎性反应之间具有密切的分子联系。一方面,多种炎性反应介质可调控自噬发生及自噬基因的转录;另一方面,自噬通过多种方式可抑制机体过激的炎性反应。因此,机体的多种炎性反应疾病包括克罗恩病(CD)可能与自噬缺陷相关。

Autophagy is an important metabolic mechanism involved in stress responses of cells such as inflamma- tion. A close molecular connection between autophagy and inflammation. On the other side, some inflammatory me- diators can regulate autophagy and its translation; Autophagy is able to suppress the excessive inflammation through various pathway. Therefore, deficient autophagy may associate with inflammatory diseases such as Crohn＇s disease （CO）.