清热益气法对初发2型糖尿病病人胰岛功能的保护机制研究

Study on the Protection Mechanism of Qingre Yiqi Method on the Islet Function in Patients with New-onset Type 2 Diabetes

目的研究清热益气法对初发2型糖尿病胰岛β细胞功能的影响。方法将符合标准的初发2型糖尿病病人120例,随机分为对照组、中药组(津力达颗粒)、西药组(二甲双胍片)、结合组(津力达颗粒加二甲双胍)。4组均干预3个月,随访3个月。观察4组治疗前后空腹血糖(FPG)、餐后2h血糖(2hFPG)及糖化血红蛋白(HbA1c)、体重指数(BMI)、胰岛β细胞功能(HOMA-β)和胰岛素抵抗指数(HOMA-IR)的变化。结果津力达颗粒联合二甲双胍组显著降低空腹血糖、2hFPG及HbA1c(P<0.01),显著降低BMI;显著升高HOMA-β,HOMA-IR显著下降(P<0.01)。明显改善中医症状。结论具有清热益气功效的津力达颗粒能明显改善病人口干、口苦;多食易饥;乏力倦怠、口渴多饮的症状,联合二甲双胍对初发2型糖尿病能有效降糖,降低体重,保护胰岛β细胞功能。

Objective To investigate the effect of Qingre Yiqi method on the islet function in patients with new onset type 2 diabetes.Methods One hundred and twenty patients with new onset type 2 diabetes were randomly divided into control group, Jinlida gran -ule group, metformin group, combined group （ Jinlida granule plus metformin） .The fasting plasma glucose （ FPG） , postprandial plas -ma glucose （ 2 h FPG）and glycated haemoglobin （ HbA1c） , body mass index （ BMI） , islet beta cell function （ HOMA beta）and insu -lin resistance index （ HOMA IR）were observed.Results The levels of FPG, 2 h FPG, HbA1c, BMI reduced significantly while HOMAbeta, HOMA IR decreased significantly in combined group （ P 〈0.01） .The symptoms of traditional Chinese medicine （ TCM）wereimproved in combined group.Conclusion Jinlida granule and metformin have the hypoglycemic effect, can significantly improve thesymptoms of TCM, reduce weight, and protect the islet function in patients with new onset type 2 diabetes.