头颈部肿瘤涎腺放射性损伤的防治研究进展

Recent progress in protecting salivary gland function after radiotherapy for patients with head and neck cancers

放射性涎腺损伤是头颈部肿瘤患者放射治疗后最常见的并发症之一，表现为口腔疼痛，说话、吞咽困难等症状，严重影响患者的生存质量。因此，涎腺放射性损伤的防治十分重要。本文从放疗保护药物、放疗技术、分子生物学等方面，针对头颈部肿瘤涎腺放射性损伤的预防与治疗予以综述。

Radiation-induced salivary glands damage is one of the most frequent complications of head and neck cancers after radiation therapy. It leads to a series of symptoms which severely affect the quality of life, such as soreness of mouth, difficult talking, dysphagia and so on. Therefore, it is important to protect the function of salivary glands. In this review, relevant approaches to protecting the function of salivary glands after receiving the radiotherapy are discussed from several aspects,such as radioprotective drugs, radiotherapy technology molecular biology.