平顶山市喹诺酮类抗菌药的不良反应及对策研究

Adverse Reactions and Countermeasures of Quinolone in Pingdingshan

目的:了解平顶山三家医院临床使用喹诺酮类药物不良反应的发生情况,分析发生的原因,探索有效的应对策略,减少类似不良反应的发生。方法:对2014年7月至2016年7月门诊的328例服用喹诺酮类抗菌药物而引发的不良反应资料进行回顾性分析,对患者年龄、不良反应发生时间、累计系统、器官及临床表现、转归等进行统计分析。结果:男性发生率高于女性,40岁左右发生率最高(P<0.05);静脉注射不良反应大于口服(P<0.05);使用左氧氟沙星引起不良反应的比例高于其他喹诺酮类药物(P<0.05),消化系统不良反应发生率高于其他系统。20~40岁间的患者恢复速度高于其他组(P<0.05)。结论:氟喹诺酮类药物在临床使用过程中易出现多种不良反应,需采取有效的对策,从而提高临床治疗效果。

Objective： To study the incidence of adverse effects of quinolones in three hospitals in Pingdingshan, analyzing the causes and exploring effective strategies to reduce the occurrence of similar adverse reactions. Methods： 328 cases of adverse reaction of quinolone from July 2014 to July 2016 were retrospectively analyzed. The patients＇ age, adverse reaction time, cumulative system, organ and clinical manifestations were analyzed retrospectively. Results： The incidence of male was higher than that of females （P〈0.05）. The incidence of adverse reactions was higher than that of other quinolones （P〈0.05）. The incidence of adverse reactions was higher than that of females （P〈0.05））, The incidence of adverse reactions in the digestive system is higher than other systems. The recovery rate was higher in patients aged 20-40 years than in other groups （P〈0.05）. Conclusion： Fluoroquinolones are prone to various adverse reactions during clinical using, and effective measures are needed to improve the clinical therapeutic effect.