儿童过敏性紫癜免疫机制研究

Immune pathogenesis of Henoch - Schonlein purpura in children

过敏性紫癜（Henoch—Schonleinpur pura，HSP）是一种以免疫复合物在受累组织小血管内皮沉积为主要特征的、多种免疫介导的系统性免疫性血管炎。HSP病因复杂，感染、食物、药物等均可导致发病。其确切发病机制至今仍未完全清楚，可能与机体免疫功能异常，IgA免疫复合物沉积、T淋巴细胞失调、B淋巴细胞异常活化、白细胞介素（IL）-17、IL-21、IL-6、IL-8、内脂素等分泌增多及肠道黏膜屏障功能受损有关。

Henoch Schonlein purpura （HSP） is a multiple immune mediated systemic immune vasculitis with an immune complex characterized by deposition of small blood vessels in the affected tissue. HSP complex etiology, in- fection, food and drugs can cause disease. Its exact pathogenesis is still not clear, may be related to abnormal immune functions, IgA immune complex deposition, T lymphocyte dysfunction, abnormal lymphocyte activation, B interleukin （IL） -17, IL- 21, IL-6, visfatin, IL- 8 secretion, and intestinal mucosal barrier dysfunction and so on.