玻璃酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对干眼症患者症状改善情况的影响研究

Effects of Sodium Hyaluronate Eye Drops Combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye Drops on Symptom Improvement in Patients with Dry Eye

目的探讨玻璃酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对干眼症患者症状改善情况的影响。方法选取2014年3月—2016年3月宁夏医科大学附属第二医院90例干眼症患者,采用随机数字表法将患者分成两组,观察组和对照组,每组45例。对照组患者单独使用玻璃酸钠滴眼液;观察组患者使用玻璃酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液。观察两组患者的治疗效果及治疗前后基础泪液分泌试验(SchirmeⅠ)、泪膜破裂时间(BUT)、SAI、SRI。结果观察组患者总有效率为93.33%(42/45),对照组为80.00%(36/45),观察组总有效率明显高于对照组,差异有统计学意义(χ~2=4.265,P=0.012)。治疗前两组患者SchirmeⅠ、BUT、SAI、SRI比较,差异均无统计学意义(P>0.05);治疗后观察组患者SchirmeⅠ、BUT较对照组升高,SAI、SRI较对照组降低,差异有统计学意义(P<0.05)。结论玻璃酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对干眼症患者症状有明显的改善效果,能够延长泪膜破裂时间,降低角膜地形图指标,修复角膜上皮。

Objective To evaluate the effects of sodium hyaluronate eye drops combined with recombinant bovine basic fibroblast growth factor eye drops on symptom improvement in patients with dry eye. Methods 90 cases of dry eye patients were selected from the Second Affiliated Hospital of Ningxia Medical University from March 2014 to March 2016,divided into two groups by random number table,the observation group and the control group,45 cases in each group. The patients in the control group were treated with sodium hyaluronate eye drops alone,while the observation group was treated with sodium hyaluronate eye drops combined with recombinant bovine basic fibroblast growth factor eye drops. The therapeutic effects of the two groups were observed,and the basal tear secretion test（ Schirme Ⅰ）,tear film break-up time（ BUT）,SAI and SRI were observed before and after treatment. Results The total effective rate was 93. 33%（ 42/45） in the observation group and 80. 00%（ 36/45） in the control group. The total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant（ χ~2= 4. 265, P = 0. 012）. Before treatment, there was no significant difference in Schirme Ⅰ,BUT,SAI,SRI between two groups（ P 〉 0. 05）,after treatment,the Schirme Ⅰ,BUT in the observation group were higher than those in the control group, SAI and SRI were lower than those in the control group, the difference was statistically significant（ P 〈 0. 05）. Conclusion Sodium hyaluronate eye drops combined with recombinant bovine basic fibroblast growth factor eye drops have a significant effect on the symptoms of dry eye patients,can prolong the break-up time,reduce the corneal topography index,corneal epithelial repair.