超敏C反应蛋白和SIOOB蛋白与急性脑梗死的相关性

Correlation between high-sensitivity C-reactive protein and SIOOB protein and acute cerebral infarction

目的:探讨脑梗死患者血清hs-CRP及S100B蛋白水平与脑梗死发生的相关性,为临床诊断治疗提供依据。方法:选择接受治疗的脑梗死患者l07例(急性脑梗死组),根据梗死面积分为:大面积(>3.5 cm^2)、中面积(1.5~3.5 cm^2)、小面积(<1.5 cm^2);对照组为82例同期健康体检者,比较两组hs-CRP及S-IOOB蛋白水平。结果:急性脑梗死组血浆hs-CRP、S100B蛋白水平显著高于对照组(P<0.000 1),大面积梗死与中面积梗死,中面积梗死与小面积梗死相比较hs-CRP及S100B蛋白水平差异有统计学意义(P<0.000 1),hs-CRP与S100B(r=0.89,P<0.05)、入院时NIHSS评分分值(r=0.67,P<0.05)呈正相关,入院时NIHSS评分分值与S100B呈正相关(r=0.55,P<0.05)。结论:血清hs-CRP联合S100B蛋白检测可以为急性脑梗死早期诊断及病情评价提供依据。

Objective：To investigate the correlation between serum hs-CRP and Sl008 protein levels in patients with cerebral infarction and the incidence of cerebral infarction. Method： The patients with acute cerebral infarction were divided into study group （ 107） , which was subdivided based on infarction area into big area（〉3.5 cm2）, middle area （J.5~3.5 tin） and small area （〈1.5 cm2）, and the control group （82） before a comparison of their hs-CRP and S-IOOB protein. Result：The levels of hs-CRP and Sl008 in the acute cerebral infarction group were significantly higher than those in the control group （P〈0.0001）, hs-CRP and SIOOB （ r=0.89, P〈0.05） , NIHSS score at admission （ r= 0. 67, P〈0. 05 ） , and the difference was statistically significant （ P〈R=0. 55, P〈0. 05 ） . There was a positive correlation between NIHSS score and S100B at admission （ r=0. 55, P〈0. 05 ） . Conclusion： Serum hs-CRP combined with Sl008 protein can provide some advice for the early diagnosis and evaluation of acute cerebral infarction.