玉屏风散辅助氯雷他定对小儿过敏性鼻炎患者疗效、免疫功能及CRP水平影响研究

Effect of Yupingfeng Powder Assisted Loratadine on the Efficacy,Immunological Function and CRP Level in Children with Allergic Rhinitis

目的 :探讨玉屏风散辅助氯雷他定对小儿过敏性鼻炎患者的疗效、免疫功能及CRP水平的影响研究。方法 :将108例小儿过敏性鼻炎患者按照数字表法随机分为两组。对照组54例给予氯雷他定治疗,观察组54例在对照组基础上加用玉屏风散。比较两组患者临床疗效、免疫功能的差异,并分析其CRP及生活质量评分。结果 :观察组临床总有效率、显效率分别为96.3%、70.4%高于对照组81.5%、46.3%;治疗2周后、治疗4周后观察组CD3、CD4和CD8细胞水平升高,也高于同期对照组,呈升高趋势(P<0.05);治疗2周后、治疗4周后观察组CRP水平降低,也低于同期对照组,呈降低趋势(P<0.05);治疗2周后、治疗4周后观察组生活质量评分升高,也高于同期对照组,呈升高趋势(P<0.05)。结论 :玉屏风散辅助氯雷他定治疗小儿过敏性鼻炎患者效果佳,临床有效率高,改善机体免疫功能及生活质量,降低炎性指标,值得临床选择。

Objective ：To investigate the effect of Yupingfeng Powder assisted loratadine on the efficacy,immunological function and CRP level of patients with allergic rhinitis in children. Methods ：108 patients with allergic rhinitis in our hospital were randomly divided into two groups according to the digital table method. In the control group,54 patients were treated with loratadine,54 cases of observation group on the basis of the control group plus Yupingfeng Powder. The differences of clinical efficacy and immune function between the two groups were compared and the CRP and quality of life scores were analyzed. Results ：The total effective rate and significant effective rate were 96.3% and 70.4% in the observation group,higher than the control group with 81.5% and 46.3%,comparison was statistically significant（P0.05）. After 2 weeks and 4 weeks of treatment,the levels of CD3,CD4 and CD8 were increased in the observation group,also higher than the control group,was gradually increased trend,comparison was statistically significant（P0.05）. After 2 weeks and 4 weeks of treatment,CRP level in the observation group was decreased,also lower than the control group,was gradually decreased trend,comparison was statistically significant（P0.05）. After 2 weeks and 4 weeks of treatment,the quality of life scores of the observation group was increased,also higher than the control group,was gradually increased trend,comparison was statistically significant（P0.05）. Conclusion ：Yupingfeng Powder assisted loratadine is effective in children with allergic rhinitis. The clinical efficacy is high,the immune function and quality of life are improved and the inflammatory index is reduced. It is worthy of clinical choice.