宫颈癌相关肿瘤标志物的检测进展

Advance in Detection of Cervical Cancer Related Tumor Markers

宫颈癌是严重危害女性健康的恶性肿瘤,从宫颈病变到宫颈癌病程较长,早期、及时、准确诊断才能采取相应措施有效地预防和终止病情的发展。宫颈癌的诊断方法多种多样,肿瘤标志物检测是常用方法之一,其因客观、无创、便捷而发挥重要作用。近年来,糖类抗原125、p53、p16/Ki-67等血清肿瘤相关标志物在宫颈癌筛查、诊断和预后评估中的作用不可忽视,为宫颈癌的早期诊断及预后判断提供了依据。因此,更准确地了解肿瘤标志物在宫颈癌检测过程中的不同侧重点具有重要的临床意义。

Cervical cancer is a malignant tumor that severely impairs health of the female. The course of disease from cervical lesions to cervical cancer is long. EarJy, timely, exact diagnosis and effective mcesures could prevent and terminate the progress of the disease. Diagnostic methods of cervical cancer are varied, and serum tumor marker is a common one. Because of the advantages of objective,handy and noninvasive, serum tumor markers detection play an important role in the diagnosis of cervical cancer. In recent years, the role of serum carbohydrate antigen 125, p53, p16/Ki-67 and other related tumor markers cannot be ignored in the assessment of cervical cancer screening, diagnosis and prognosis, providing basis for the early diagnosis and prognosis of cervical cancer. Therefore, more accurate understanding of tumor markers in the detection of cervical cancer with different emphases, will have great clinical significance.