RAGE及其配体钙粒蛋白S100A12在急性肺损伤中研究进展被引量：11

Review of RAGE and ligand S100A12 in the research of acute lung injury

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摘要脓毒症是临床较为常见的一种危重症,它除可引起剧烈的全身炎症反应外,还常导致肺、肝、肾、肠道、脑等多个器官的功能失常。尤其是脓毒症所致的肺损伤,其发生早,病情较重,表现为急性肺损伤（acute lung injury,ALI）或急性呼吸窘迫综合征（acute respiratory distress syndrome,ARDS）,常是患者死亡的直接原因。尽管目前监护技术及机械通气设备的进展为脓毒症所致的ALI/ARDS救治提供很大帮助,但其病死率仍高达38%~50%[1]。生理状态下, Lung injury caused by sepsis is the direct cause of death due to its early complication and severe prognosis.Recent researches proved that the increased expression of receptor for advanced glycation end products is a mark of lung epithelium damage in the disease of ALI/ARDS.The receptor for advanced glycation end products can activate inflammatory pathways and release inflammatory cytokines when combined with ligands.Monitoring soluble receptor for advanced glycation end products and its ligands can be the early diagnostic marker of ALI/ARDS.

作者陈旋熊旭东

机构地区上海中医药大学附属曙光医院呼吸科上海中医药大学附属曙光医院急诊科

出处《临床急诊杂志》 CAS 2017年第11期867-869,共3页 Journal of Clinical Emergency

关键词脓毒症急性肺损伤晚期糖基化终末产物受体 sepsisacute lung injury the receptor for advanced glycation end products

分类号 R563 [医药卫生—呼吸系统]

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1俞敏,赵赛,程怀平,田兆方.RAGE与腹腔注射脂多糖诱导新生大鼠急性肺损伤的相关性研究[J].南京医科大学学报（自然科学版）,2014,34(8):1051-1055. 被引量：6
2吴昭昭,张素萍,武彦文,刘海云,聂继华,童建.香烟烟雾吸入致大鼠肺与气管上皮细胞RAGE和S100A6表达增加[J].中华疾病控制杂志,2010,14(3):183-186. 被引量：1
3唐朝霞,管向东.急性呼吸窘迫综合征诊断标准[J].中国实用内科杂志,2013,33(11):838-839. 被引量：42

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