男性抑郁症患者自杀行为与糖脂水平及甲状腺功能的关系

Association of the shicide of male depressed patients with thyroid function levels of blood sugar and serum lipid

目的:探讨男性抑郁症患者自杀行为与糖脂水平、炎症因子、甲状腺功能的相关性。方法:收集有自杀行为(23例)和无自杀行为(112例)的男性抑郁症患者年龄、病程、受教育年限、婚姻状况、是否伴有躯体疾病、是否首发、精神疾病家族史、自杀家族史等资料,抽取空腹血标本检测空腹血糖(FBS)、血浆总胆固醇(TCH)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)及超敏C反应蛋白(hs-CRP)的水平,并进行比较和分析。结果:与无自杀行为组相比,有自杀行为组的首发抑郁症患者更多(P<0.05)、hs-CRP水平较高(P<0.05)、TSH水平较低(P<0.05)。结论:男性抑郁症患者的自杀行为与首次发病及血清hs-CRP、TSH水平有关。

Objective：To investigate the correlation of thyroid function, levels of blood sugar and serum lipid with the suicide behavior of male patients with depression. Method： The information of suicidal behavior group （n =23） and non suicidal behavior group （n = 112） of male patients with depression was collected,in- cluding age, course of the disease, the years of education, marital status, physical disease, first-episode depres- sion, family history of mental illness, family history and suicide. Fasting blood samples were taken to detect the levels of fasting blood sugar（ FBS）, total cholesterol（ TCH）, triglycerides（ TG）, high-density lipoprotein choles- terol （ HDL）, low-density lipoprotein cholesterol （ LDL ）, free triiodothyronine （ FT3 ）, free thyroxine （ FT4 ）, thy- roid-stimulating hormone（TSH） and hypersensitive c-reactive protein（hs-CRP）. Results：Compared with the depressed patients without suicide behavior, the suicide group had more patients in the first-episode （P 〈 0.05 ）, higher hs-CRP levels （ P 〈 0. 05 ）, lower level of TSH （ P 〈 0. 05 ）. Conclusion ： The suicidal behavior of male depressive patients were related with whether they are in first-episode,and levels of hs-CPR and TSH.