中药附子毒效多维评价与整合分析的思路与实践

Thought and Practice of Multidimensional Evaluation and Integrated Analysis on Toxicity and Efficacy of Radix Aconiti Lateralis Praeparata

本文针对中药安全性、有效性备受质疑的现状,系统阐述了中药毒效的认知过程和基本内涵,提出中药毒效"系统中药、多维评价、整合分析"的研究思路与方法,并以附子为例,系统研究评价附子毒效在系统中药中"品种、品质、制药、药性、功效、应用"的表现形式,整合分析附子"毒效"的物质基础、作用机制和增效解毒原理。

Currently,the safety and efficacy of Chinese materia medica have been questioned. Encountering that situation,this paper systematically elaborated on the cognitive process and basic connotation of the toxicity and efficacy of Chinese materia medica. A new thought and methodology of ＂multidimensional evaluation and integrative analysis of the toxicity and efficacy of TCM＂was proposed. Taking Radix Aconiti Lateralis Praeparata as an example,the breeds,quality,pharmaceutical manufacture,medicinal properties,medicinal effects,and application of Radix Aconiti Lateralis Praeparata were used to evaluate the toxicity and efficacy systematically. Furthermore,the material basis,mechanism,and principle of effect-enhancing and toxicity-reducing of Radix Aconiti Lateralis Praeparata were integrated analyzed.