维生素D对急性腹泻患儿血清25(OH)D与炎症因子水平的影响

Effect of vitamin D supplement on levels of serum 25-hydroxvitamin D and inflammatory factors in children with acute diarrhea

目的探讨补充维生素D对急性腹泻患儿血清25-羟维生素D[25-hydroxvitamin D,25(OH)D]与炎症因子水平的影响。方法选取2013年12月—2016年12月扬州大学附属医院确诊治疗的急性腹泻患儿100例,依据治疗方法分为A组和B组,每组50例,A组给予常规对症治疗,B组在A组常规对症治疗的基础上给予维生素D。结果 A组和B组治疗有效率分别为80.00%和96.00%,B组明显高于A组,差异有统计学意义(P<0.05)。A组和B组呕吐、大便次数和性状复常时间分别为(4.45±0.54)d和(3.73±0.51)d、(4.75±0.57)d和(3.82±0.53)d、(2.33±0.36)d和(1.92±0.30)d,B组明显低于A组,差异有统计学意义(P<0.05),但两组不良反应发生率,差异无统计学意义(P>0.05);B组治疗后血清25(OH)D水平明显高于A组,B组血清白细胞介素6(interleukin 6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平明显低于A组,B组治疗后上述指标变化值明显高于A组,差异有统计学意义(P<0.05)。结论补充维生素D治疗可有效提高急性腹泻患儿的治疗疗效,其可能与改善机体25(OH)D水平和炎症状态有关,且具有良好的安全性。

Objective To explore the effect of vitamin D supplement on the levels of serum 25-hydroxvitamin D [25 （OH）] and inflammatory factors in children with acute diarrhea. Methods A total of 100 children with acute diarrhea in the hospital from December 2013 to December 2016 were selected and randomly divided into Group A and Group B, with 50 cases in each group, and Group A was given the routine treatment and Group B was given vitamin D supplement treatment on the routine treatment basis. Results The therapeutic effective rate of Group B（96.00%） was significantly higher than that of Group A（80.00%）, and the vomiting （3.73±0.51） d vs （4.45±0.54） d and defecate frequency（3.82±0.53） d vs （4.75±0.57） d, and feces character recovery time （1.92±0.30） d vs （2.33±0.36） d of Group B were significantly lower than those of Group A, anti the difference was statistically significant （P 〈 0,05）, but the adverse reaction rates of the two groups were basically the same （P 〉 0.05）. The serum 25 （OH） D level of Group B was significantly higher than that of Group A, the serum interleukin 6 （IL-6） and tumor necrosis factor-α （TNF-α） levels of Group B were significantly lower than those of Group A, and after treatment, the above taetors of Group B were significantly higher than those of Group A, and the difference was statistically significant （P 〈 0.05）. Conclusion Vitamin D supplement treatment can effectively improve the curative effect in children with acute diarrhea, its potential may be related to improving the body＇s 25 （OH） D levels and inflammatory state, and it also has a good security.