八珍汤雾化吸入辅助治疗恶性肿瘤临床研究

Clinical Study of Adjuvant Therapy of Bazhen Decoction Nebulized Inhalation for Patients with Malignant Tumors

目的:观察中药八珍汤雾化吸入辅助治疗恶性肿瘤的临床疗效及对患者免疫功能的影响。方法:将80例中晚期恶性肿瘤患者随机分为治疗组和对照组,各40例,两组均采取常规单纯放疗或放、化疗联合方案。观察组在常规治疗的基础上加用中药八珍汤雾化吸入。比较两组患者生存质量、不良反应及临床疗效,检测血清中CD3+、CD4+、CD8+水平。结果:治疗组患者生存质量的改善率为50.0%,明显高于对照组的22.5%,两组比较,差异有统计学意义(P<0.05)。治疗组有效率为85.0%,对照组有效率为60.0%,两组比较,差异有统计学意义(P<0.05)。观察组患者Ⅲ~Ⅳ级不良反应为4例,显著少于对照组的11例,差异有统计学意义(P<0.05)。治疗后,治疗组患者CD3+和CD4+水平明显高于对照组,CD8+水平明显低于对照组,差异有统计学意义(P<0.01)。结论:中药八珍汤雾化吸入辅助治疗恶性肿瘤疗效明显,且可调整患者的免疫功能。

Objective： To observe effect of adjuvant therapy of Bazhen decoction nebulized inhalation for the radiation and chemotherapy patients with malignant tumors and the influence of immune function. Method： 80 cases with advanced malignant tumors were randomly divided into the control group and the treatment group. All cases were treated with routinal radiotherapy or chemotherapy. In addition,treatment group was nebulized inhalation of Bazhen decoction. Life quality,toxic reaction,and efficacy were compared between two groups. Serum levels of CD3＋,CD4＋,CD8＋was were detected in two groups. Results： Improvement rate of treatment group was 50. 0%,which was remarkably higher than control group 22. 5%（ P〈0. 05）. The effective rate of treatment group was 85. 0%,which was evidently higher than control group 60. 0%（ P〈0. 05）. Ⅲ-Ⅳ toxic reaction of treatment group was 4 cases,which obviously lower than control group 11 cases（ P〈0. 05）. After treatment,serum levels of CD3＋and CD4＋were remarkably higher,while CD3＋was lower,than control group（ P〈0. 01）. Conclusion： Efficacy of Bazhen decoction nebulized inhalation for patients with radio chemotherapy is obvious,and up-regulate immune function.