重视角膜上皮屏障功能的保护

Emphasizing the protection of corneal epithelial barrier function

角膜缘干细胞是角膜上皮细胞健康、更新与修复的关键。角膜上皮屏障功能的完整性对于维系眼表健康尤其是角膜的透明性十分重要,它不仅可维持正常代谢所需眼内外营养物质的交换,也可抵御有害物或微生物侵袭。遗传、外伤、炎症、代谢、药物及手术等因素,均会影响角膜上皮屏障功能。针对角膜上皮屏障功能治疗重点是去除病因、促进上皮功能的恢复及重建眼表平衡等。本文中笔者对角膜上皮屏障的构成、角膜上皮功能障碍及角膜上皮屏障功能的保护与治疗策略等方面进行评述。

Limbal stem cells are the key to the health,renewal and repair of corneal epithelial cells.The integrity of the corneal epithelial barrier function is important for maintaining ocular surface health,especially the transparency of the cornea,not only to maintain the normal metabolism of essential nutrients within the eye exchange,but also against harmful substances or microbial invasion. Genetic,traumatic,inflammatory,metabolic,drug,surgery and other factors,will affect the corneal epithelial barrier function.The focus of treatment is to remove the causes,promote the recovery of epithelial function and reconstruct the ocular surface balance. In this paper,the composition of the corneal epithelial barrier,the dysfunction of the corneal epithelium,the protection of the corneal epithelial barrier function and the treatment strategy are reviewed.