摘要
目的观察和解分消法联合西医常规治疗对慢性肾脏病3~4期患者T细胞亚群、骨代谢及肾功能的影响。方法将128例慢性肾脏病3~4期患者随机分为2组,对照组64例予西医常规治疗,治疗组64例在对照组治疗基础上加用中医和解分消法治疗,2组均以3个月为1个疗程。观察2组治疗前后T细胞亚群(CD4^+、CD8^+、CD4^+/CD8^+)、骨代谢指标[血清钙(Ca)、磷(P)、骨钙素(BGP)]、肾功能指标[血肌酐(SCr)、内生肌酐清除率(Ccr)、尿素氮(BUN)、肾小球滤过率(GFR)]、炎症指标[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]及中医证候评分变化情况,统计2组治疗1个疗程后的临床疗效。结果治疗组治疗后CD4^+、CD4^+/CD8^+均明显高于治疗前及对照组(P均<0.05),CD8^+明显低于治疗前及对照组(P均<0.05);2组治疗后血清Ca、BGP、Ccr、GFR均明显升高(P均<0.05),且治疗组各指标水平均明显高于对照组(P均<0.05);2组治疗后血清P、SCr、BUN水平和中医证候评分均明显降低(P均<0.05),且治疗组各指标水平和中医证候评分均明显低于对照组(P均<0.05)。2组治疗后hs-CRP水平均明显降低(P均<0.05),治疗组治疗后IL-6、TNF-α水平均明显低于治疗前及对照组(P均<0.05)。治疗1个疗程后,治疗组总有效率明显高于对照组(P<0.05)。结论和解分消法联合西医常规治疗慢性肾脏病3~4期患者疗效优于单纯西医治疗,可显著改善肾功能和骨代谢指标,减轻炎症反应。
Objective It is to observe the effect of Hejie Fenxiao therapy combined with western medicine on T cell subsets, bone metabolism and renal function in patients with chronic kidney disease at 3-4 stage. Methods 128 patients with chronic kidney disease at 3-4 stage were randomly divided into two groups: the control group of 64 eases treated with conventional western medicine therapy, the treatment group of 64 cases treated with traditional Chinese medicine Hejie Fenxiao drugs based on the treatment in the control group. Both groups were treated for 3 months. The changes of T cell subsets ( CD4+ , CD8+ and CD4+/CD8+ ), bone metabolism indexes [ serum calcium ( Ca), phosphorus (P) and Osteo- calcin (BGP) ] , renal function indexes[ serum creatinine(SCr) , creatinine clearance rate (CCr) , urea nitrogen (BUN) , glomerular filtration rate (GFR) ], and inflammatory markers [ high sensitivity C reactive protein (hs-CRP) and interleu- kin-6 (IL-6), tumor necrosis factor alpha (TNF-α) ] and scores of syndrome before and after treatment were observed, the clinical curative effects were evaluated in both groups. The 2 groups were observed before and after treatment of TCM syn- drume score. Results After treatment, the levels of CD4+ and CD4 +/CD8+ in the treatment group were significantly lower while that of CD8+ was higher than those before treatment and in the control group (P 〈0.05). After treatment, serum Ca and BGP, Ccr and GFR were increased obviously, while serum P, SCr and BUN, scores of syndrome were decreased sig- nificantly in both groups ( P 〈 0.05 ), and the decrease or increase of these indexes in the treatment group were more signif- icant than those in the control group ( P 〈 0.05 ). After treatment, the level of hs-CRP was lower than that before treatment in both groups (P 〈 0.05) , the levels of IL-6 and TNF-α in the treatment group were lower than that before treatment and in the control group (P 〈 0.05 ). The total effective rate in the treatment group was higher than that in the control group (P 〈 0. 05). Conclusion Hejie Fenxiao therapy combined with western medicine can significantly improve renal function and bone metabolism indexes, relieve inflammation in the treatment of chronic kidney disease at 3-4 stage, its curative is better than simple western medicine.
出处
《现代中西医结合杂志》
CAS
2018年第2期119-122,142,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
新疆维吾尔自治区科技计划项目(20140215)
关键词
慢性肾脏病
T细胞亚群
骨代谢
肾功能
和解分消法
chronic kidney diseases
T cell subsets
bone metabolism
renal function
Hejie Fenxiao therapy