女性原发性尿道癌5例报告

Clinical analysis of primary female urethral carcinoma:a report of 5 cases

目的分析女性原发性尿道癌的流行病学特征、病因、临床特点以及治疗、预后等。方法回顾性分析2011~2016年于我院就诊的5例女性原发性尿道癌患者的临床资料,并对患者进行随访,了解复发和生存情况。结果本组5例女性尿道癌患者年龄40~68岁,主要临床表现包括排尿困难、血尿及尿道口肿物等,所有患者均由病理诊断为尿道癌并行手术治疗。患者随访时间4~48月,目前3例无瘤生存,1例发生远处转移,1例失访。结论女性原发性尿道癌是一种发病率极低的恶性肿瘤,临床表现缺乏特异性,预后较差,对于早期、位于远端尿道的肿瘤可行部分尿道切除术或放疗,对于进展期或位于近段尿道的肿瘤需采取手术和放化疗相结合的综合治疗方案。

Objective To investigate the epidemiology,etiology, clinical characteristics, management and prognosis of pri- mary female urethral carcinoma. Methods The clinical data of 5 female cases of primary urethral carcinoma treated in our hospital during 2011 and 2016 were retrospectively analyzed. All patients were followed up to observe the recurrence and sur- vival. Results The patients aged 40-68 years, with main clinical manifestations of dysuria, hematuria and extraurethral mass. All cases were confirmed with pathological examination and treated with surgery. One case was loss to follow-up, and the other 4 cases were followed up for 4-48 months,3 of whom survived free of cancer,while 1 had distant metastasis. Conclusions Primary female urethral carcinoma is among the rarest types of neoplasia,with various clinical manifestations and poor prognosis. Small, superficial, distal urethral tumors may be treated with excision of the distal urethra or radiotherapy. For advanced or proximal female urethral carcinoma, a combination of chemotherapy, radiotherapy and surgery is recommended for optimal local and distant disease control.