摘要
脑缺血事件发生后在缺血区域引起大量的神经细胞凋亡,加重了脑组织损害,其机制主要是脑缺血发生后细胞内源性凋亡路径和外源性凋亡路径被启动,产生一系列生化级联反应引起神经细胞凋亡,阻止细胞缺血后生化级联反应,防治细胞凋亡是脑缺血治疗药物研究的要点。论文就当前中药及中药有效成分干预脑缺血后细胞内源性凋亡路径和外源性凋亡路径的研究现状作一综述。
Cerebral ischemic events in the ischemic area caused a large number of nerve cell apoptosis, increased brain damage, the mechanism is mainly due to cerebral ischemia after the endogenous apoptotic pathway and exogenous apoptotic pathway is started. A series of biochemical cascade reactions cause neuronal apoptosis, blocking the post- ischemic post-ischemic biochemical cascade, and preventing and treating apoptosis are the key points in the research of therapeutic agents for cerebral ischemia. In this paper, the current research status of the intervention of active ingre- dients of traditional Chinese medicine and traditional Chinese medicine on endogenous apoptotic pathway and extrinsic aoontosis pathway after cerebral isehemia is reviewed.
出处
《中医药临床杂志》
2017年第12期2136-2139,共4页
Clinical Journal of Traditional Chinese Medicine
关键词
脑缺血
细胞凋亡
内源性路径
外源性路径
中药
Cerebral ischemia
Apoptosis
Endogenous pathways
Exogenous pathways
Traditional Chinese medicine