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血清生长分化因子-15、C反应蛋白在慢性阻塞性肺疾病中的表达水平 被引量:13

Expression level and clinical value of serum growth differentiation factor-15 and C reactive protein in chronic obstructive pulmonary disease
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摘要 目的观察血清生长分化因子-15及C反应蛋白在慢性阻塞性肺疾病(COPD)中的表达水平及临床意义。方法回顾性分析2015年2月~2017年5月在山东省临朐县人民医院就诊的239例COPD患者的临床资料,根据病情分为稳定期患者136例,急性期患者103例,同时选取健康体检者80名,纳入对照组。所有入选者进行血清生长分化因子-15及C反应蛋白测定,观察上述指标在三组中的表达情况。同时描绘受试者工作曲线,对上述指标在诊断COPD中的灵敏度、特异性等进行分析。结果生长分化因子-15及C反应蛋白在对照组、COPD稳定期组、COPD急性期组中依次升高,三组比较差异有统计学义(P<0.01)。生长分化因子-15诊断COPD急性期的曲线下面积为0.79(95%CI:0.61~0.89,P<0.01),诊断准确率为72%。C反应蛋白诊断COPD急性期的曲线下面积为0.66(95%CI:0.51~0.76,P<0.01),诊断准确率为61%。结论 GDF-15和CRP在COPD患者中的表达水平明显升高,并与病情严重程度相关;GDF-15在诊断COPD中的准确性要高于CRP。 Objective To observe the expression level and clinical significance of serum growth differentiation factor- 15 and C reactive protein in chronic obstructive pulmonary disease. Methods From February 2015 to May 2017 in 239 cases of COPD patients in Linqu People's Hospital of Shandong Province. Grouped according to the patient's condition: 136 stable patients, 103 cases of patients in acute stage at the same time, 80 healthy volunteers were selected as control group. All patients were selected for determination of serum growth differentiation factor -15 and C reactive protein, the expression levels of the above indexes in the three groups were analyzed. The ROC curve was used to analyze the sensitivity and specificity of the above indexes in the diagnosis of COPD. Results Growth differentiation factor-15 and C reactive protein in the control group, stable COPD group, acute COPD group were significantly increased, the difference between the three groups are statistically significant (P 〈 0.01). The area of growth differentiation factor-15 in the diagnosis of acute COPD curve was 0.79 (95%CI: 0.61-0.89, P 〈 0.01), the diagnostic accuracy was 72%. The area under the curve of C reactive protein in the diagnosis of acute COPD was 0.66 (95%CI: 0.51-0.76, P 〈 0.01), and the diag nostic accuracy was 61%. Conclusion The expression levels of GDF-15 and CRP in patients with CRP are significantly increased, and positively correlated with the severity of the disease, the accuracy of GDF-15 in the diagnosis of COPD is higher than that of CRP.
出处 《中国医药导报》 CAS 2018年第1期68-71,共4页 China Medical Herald
关键词 慢性阻塞性肺疾病 生长分化因子-15 C-反应蛋白 受试者工作曲线 Chronic obstructive pulmonary disease Growth differentiation factor-15 C-reactive protein Receiver operating curve
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