百令胶囊联合呼吸康复训练治疗慢阻肺的疗效及对患者血气指标、肺功能的影响

Effects of Bailing Capsule Combined with Respiratory Rehabilitation Training on Chronic Obstructive Pulmonary Disease(COPD) and Influence on Blood Gas and Lung Function

目的:探讨百令胶囊联合呼吸康复训练对慢阻肺的治疗效果及对患者血气指标、肺功能的影响。方法:选取2014年2月至2016年12月焦作市人民医院收治的慢阻肺患者282例,依据治疗方式不同分为对照组(n=126)和观察组(n=156),2组患者均给予解痉平喘、控制感染,祛痰等常规治疗,对照组给予百令胶囊,观察组在对照组的基础上结合呼吸康复训练。比较2组治疗后临床疗效,治疗前后肺功能变化、血气分析及6 min步行距离(6MWD)。结果:治疗后,观察组总有效率较对照组明显升高(P<0.05);治疗后2组FEV_1、FVC、FEV_1/FVC及FEV%pre明显增加,且观察组各项肺功能指标均明显大于对照组(P<0.05或P<0.01);治疗后2组PaO_2和SaO_2明显升高,PaCO_2明显降低,2组间差异有统计学意义(P<0.05或P<0.01);治疗后1~3个月2组6MWD均呈逐渐增加趋势,并明显大于治疗前,且治疗后1~3个月观察组6MWD均明显大于对照组(P<0.05或P<0.01)a。结论:百令胶囊配合呼吸康复训练可明显缓解慢阻肺患者呼吸困难等临床症状,改善肺通气换气功能,平衡血气指标,增加患者运动耐力,提高整体治疗效果。

Objective： To study the effects of Bailing capsule combined with respiratory rehabilitation training on chronic obstructive pulmonary disease（ COPD） and influence on blood gas and lung function. Methods： A total of 282 patients with COPD in our hospital from February 2014 to December 2016 were divided into control group（ n = 126） and observation group（ n = 156） according to different treatment methods. All patients were given antispasmodic asthma,control of infection,expectorant and other conventional treatment. The control group was given bailing capsule and the observation group was combined with respiratory rehabilitation training on the bases of control group. The clinical efficacy of the 2 groups after treatment,the lung function,blood gas,6 min walking distance（ 6 MWD） before and after treatment were compared. Results： After treatment,the total effective rate in the observation group was significantly higher than control group（ P〈0. 05）. Meanwhile,the FEV_1,FVC,FEV_1/FVC and FEV%pre were significantly increased,and the lung function indexes of the observation group were significantly higher than those of the control group（ P〈0. 05 or P〈0. 01）. After treatment,the PaO_2 and SaO_2 were significantly higher,and PaCO_2 decreased significantly in 2 groups. There was significant difference between 2 groups（ P〈0. 05 or P〈0. 01）. After 1-6 months of treatment,6 MWD showed a gradual increase trend,and significantly greater than before treatment. 6 MWD of treatment group after 1 ~ 3 months of treatment was significantly greater than that of the control group（ P〈0. 05 or P〈0. 01）. Conclusion： Bailing capsule combined with respiratory rehabilitation training can relieve the clinical symptoms such as dyspnea in patients with COPD,improve lung function,balance blood gas index,increase patient＇s athletic endurance and improve the overall therapeutic effects.