老年原发性高血压患者血尿酸与代谢综合征各组分相关关系研究

Relationship between serum level of uric acid and components of metabolic syndrome in elderly essential hypertensive patients

目的探讨老年原发性高血压患者血尿酸与代谢综合征的相关性。方法选取2014年2月~2016年3月在首都医科大学宣武医院心脏科门诊就诊的老年原发性高血压患者201例,根据患者血尿酸水平分为高尿酸血症组47例和尿酸正常组154例。男性血尿酸>420μmol/L,女性血尿酸>360μmol/L定义为高尿酸血症。应用Pearson相关分析与logistic回归分析血尿酸与老年原发性高血压患者代谢综合征各组分的相关性。结果与尿酸正常组比较,高尿酸血症组年龄、体质量指数、腰围、血肌酐、空腹血糖、TG、代谢综合征、腹型肥胖、高血糖及高TG血症比例明显升高,HDL-C水平明显降低,差异有统计学意义(P<0.05,P<0.01)。Pearson相关分析显示,体质量指数、腰围、空腹血糖及TG与血尿酸呈正相关,而HDL-C与血尿酸呈负相关(P<0.05,P<0.01)。logistic回归分析显示,腰围(OR=1.080,95%CI:1.035~1.127,P=0.000)和TG(OR=1.472,95%CI:1.021~2.122,P=0.038)是血尿酸升高的独立危险因素。结论老年原发性高血压患者血尿酸水平与代谢综合征及各组分密切相关,其中腰围和TG是发生高尿酸血症的独立危险因素。

Objective To study the relationship between serum uric acid（UA）level and metabolic syndrome（MS）in elderly essential hypertensive（EH）patients.Methods Two hundred and one elderly EH patients were divided into hyperuricemia group（n=47）and normal UA group（n=154）.Hyperuricemia was defined in males with their serum UA level 〉420μmol/L and in females with their serum UA level〉360μmol/L.Relationship between serum UA level and MS in elderly EH patients was analyzed by Pearson correlation analysis and logistic regression analysis respectively.Results The age was significantly older,the waist circumference was significantly longer,the BMI and serum SCr,FPG,TG level and the incidence of MS,central obesity,high blood glucose and high TG were significantly higher while the serum HDL-C level was significantly lower in hyperuricemia group than in normal UA group.Pearson correlation analysis showed that waist circumference,BMI,serum FPG and TG level were positively related with serum UA level while serum HDL-C level was negatively related with serum UA level（P〈0.05,P〈0.01）.Logistic regression analysis showed that waist circumference and serum TG level were the independent risk factors for elevated serum UA level in elderly EH patients（OR=1.080,95%CI：1.035-1.127,P=0.000;OR=1.472,95%CI：1.021-2.122,P=0.038）.Conclusion Serum UA level is closely related with MS and its components while waist circumference and serum TG level are the independent risk factors for hyperuricemia in elderly EH patients.