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顺尔宁联合糖皮质激素吸入和单纯糖皮质激素吸入治疗儿童哮喘的效果对比 被引量:3

Effect comparison between Singulair combined with inhaled corticosteroids and inhaled corticosteroids alone in the treatment of children with asthma
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摘要 目的探讨顺尔宁联合糖皮质激素吸入和单纯糖皮质激素吸入治疗儿童哮喘的临床效果。方法将2014年2月~2016年12月在我院接受治疗的60例儿童哮喘患者作为本次研究对象,将其按照随机数字法平均分为两组,30例采用单纯糖皮质激素吸入治疗(对照组),30例给予顺尔宁联合糖皮质激素吸入治疗(研究组)。将两组患者临床疗效、湿啰音消失时间、哮鸣音消失时间、咳嗽消失时间、住院时间、FEV1、PEF、Eos指标及不良反应发生情况进行比较。结果研究组临床总有效率为86.66%,对照组临床总有效率为63.33%,研究组患者临床总有效率显著高于对照组(P<0.05)。研究组患者湿啰音消失时间、哮鸣音消失时间、咳嗽消失时间及住院时间均显著短于对照组(P<0.05)。干预前两组患者FEV1、PEF、Eos指标比较差异无统计学意义(P>0.05),干预后两组患者FEV1、PEF指标均显著升高,Eos指标均显著降低(P<0.05),且研究组较对照组改善显著(P<0.05)。研究组不良反应发生率为6.66%,对照组不良反应发生率为10.00%。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论在儿童哮喘患者治疗中选择顺尔宁联合糖皮质激素吸入治疗可显著缩短患者临床症状消失时间及住院时间,提高治疗效果,降低患者经济负担,改善患者肺功能,且不良反应低安全有效,值得在临床上推广使用。 Objective To evaluate the clinical effect between Singulair combined with inhaled corticosteroids and inhaled corticosteroids alone in the treatment of children with asthma. Methods Sixty children with asthma treated in our hospital from February 2014 to December 2016 were selected as the subjects of this study and randomly divided into 2 groups,30 cases were treated with inhaled corticosteroid therapy (control group),30 patients were treated with Singulair combined with inhaled corticosteroid therapy (study group).The clinical efficacy,wet rales disappearance time,wheezing disappearance time,cough disappearance time,hospitalization time,FEV1,PEF,Eos index and adverse reactions were compared between the two groups. Results The total effective rate of the study group was 86.66%,and the total effective rate of the control group was 63.33%.The total effective rate of the study group was significantly higher than that of the control group (P 〈0.05).The disappearance time of rales,wheezing disappearance time,cough disappearance time and hospital stay in the study group were significantly shorter than those in the control group (P 〈0.05).Before intervention,there were no significant differences in FEV1,PEF and Eos indexes between the two groups (P 〉0.05).After intervention,the FEV1 and PEF indexes of the two groups were significantly increased,and the Eos indexes were significantly decreased (P 〈0.05),and the study group was improved significantly compared with the control group (P 〈0.05).The incidence of adverse reactions in the study group was 6.66%,and the incidence of adverse reactions in the control group was 10.00%.There was no significant difference in the incidence of adverse reactions between the two groups (P 〉0.05). Conclusion Singulair combined with glucocorticoids in the treatment of children with asthma inhalation treatment can significantly shorten the clinical symptoms disappeared time and hospitalization time,improve the therapeutic effect,reduce the economic burden of patients,improve lung function.It has low adverse reaction,and it is safe and effective,worthy of promotion in clinical use.
作者 黄冬娥 程吟
出处 《中国医药科学》 2017年第24期64-67,共4页 China Medicine And Pharmacy
关键词 顺尔宁 糖皮质激素 哮喘 儿童 Singulair Glucocorticoid Asthma Children
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