肿瘤发展过程中自噬与凋亡的相互作用

Interaction between autophagy and apoptosis during tumor development

肿瘤细胞的增殖受细胞程序性死亡的调控,自噬和凋亡同属程序性死亡的两种形式,两者在形态、功能上有显著性差异,但也存在诸多联系,其均与一系列基因的激活、表达和调控相关。本文将结合近年来国内外的研究进展,对自噬的细胞学调控,及其与凋亡相关的分子机制作一综述。旨在通过对其相互关系的归纳总结,为研究细胞自噬在肿瘤发生发展中的作用以及肿瘤相关治疗靶点的发现提供思路与线索。此外,还将探讨自噬和凋亡在肿瘤治疗中的作用并展望自噬在肿瘤治疗中的应用前景。

The proliferation of tumor cells is regulated by a complex array of signaling pathways,among these signaling pathways,the programmed cell death. Autophagy and apoptosis are two types of programmed death. There are significant differences in their morphological and functional features,but they also have many links. Both apoptosis and autophagy are involved in activation,expression and regulation of a series of genes. By reviewing the research progress in recent years,this article will discuss the cellular regulation and molecular mechanisms of their related genes. Through summarizing the relationship between autophagy and apoptosis,it aims to get a better understanding of the mechanisms of autophagy and apoptosis in tumor progression,and looking at the perspectives for studies on the autophagy and apoptosis in tumor treatment.