摘要
Dear Editor, Lifelong premature ejaculation （LPE） is a type of sexual dysfunction in males and has three characteristics： （1） an intravaginal ejaculatory latency time （IELT） of 〈 1 rain; （2） insufficient control over delaying ejaculation; and （3） negative personal consequences, such as distress, frustration, and/or the avoidance of sexual intimacy2 Its etiologies involve the 5-hydroxytryptamine （5-HT） system. The use of 5-HT transporter （5-HTT） blockers （e.g., selective serotonin reuptake inhibitors, SSRIs） was found to prevent the reuptake of 5-HT from the synaptic cleft into the presynaptic serotonergic neurons, which leads to increased extracellular 5-HT levels, thereby delaving ejaculation.
Dear Editor, Lifelong premature ejaculation （LPE） is a type of sexual dysfunction in males and has three characteristics： （1） an intravaginal ejaculatory latency time （IELT） of 〈 1 rain; （2） insufficient control over delaying ejaculation; and （3） negative personal consequences, such as distress, frustration, and/or the avoidance of sexual intimacy2 Its etiologies involve the 5-hydroxytryptamine （5-HT） system. The use of 5-HT transporter （5-HTT） blockers （e.g., selective serotonin reuptake inhibitors, SSRIs） was found to prevent the reuptake of 5-HT from the synaptic cleft into the presynaptic serotonergic neurons, which leads to increased extracellular 5-HT levels, thereby delaving ejaculation.
