同型半胱氨酸、视黄醇结合蛋白与血脂在单纯性肥胖中的表达意义分析

Analysis of homocysteine,retinol-binding protein and lipid metabolism parameter expressions in obesity

目的探讨Hcy、RBP与血脂水平在单纯性肥胖中的相关性及意义。方法选择430例肥胖者(肥胖组)和440例健康体检者(对照组)为研究对象,测定人体体质参数和血清Hcy、RBP、血脂等。结果肥胖组血清Hcy、RBP、血脂水平显著高于对照组;男性血清Hcy、RBP水平显著高于女性,高年龄组血清Hcy水平显著高于低年龄组,差异均有统计学意义(P<0.05);高年龄组血清RBP水平与低年龄组相比,差异无统计学意义(P>0.05);血清Hcy与RBP、TG、LDL呈正相关(r值分别为0.237、0.198、0.147,P<0.05);与HDL呈显著负相关(r=-0.244,P<0.01)。多元逐步回归分析,HDL、RBP是血清Hcy水平的独立相关因素(P<0.05)。结论肥胖患者血清Hcy、RBP、血脂水平表达明显紊乱,Hcy、RBP、血脂水平在肥胖相关性疾病中发挥重要作用。

Objective To explore the correlation and meaning of Hcy,RBP and lipid metabolism parameters in obese subjects.Methods 870 subjects were included in this study,and divided into the obese group（ n = 430） and the control group（ n =440）. Subjects＇ anthropometric parameters,and lipid metabolism parameters,serum RBP,Hcy were detected. Results Serum Hcy,RBP,lipid levels were significantly higher in the obese group than that in the control group. Males had significantly higher Hcy and RBP levels than females. And serum Hcy levels were significantly higher in the high age group than in the low age group,with the differences statistically significant（ P〈0. 05）; the difference of serum RBP levels between the high age group and the low age group wasn＇t statistically significant（ P〉0. 05）; in all subjects,serum Hcy levels were positively correlated with RBP,TG,LDL（ r = 0. 237,r = 0. 198,r = 0. 147,P〈0. 05）; and negatively correlated with HDL（ r =-0. 244,P〈0. 01）. Multiple stepwise regression analysis showed that HDL and RBP were independently related factors influencing serum Hcy levels. Conclusion The expression of Hcy,RBP and lipid metabolism parameters has an obvious disorder in obese group.Hcy,RBP and lipid metabolism parameters play an very important role to correlated disease in obesity group.