白藜芦醇对糖尿病及其并发症作用机制的研究进展

Research progress on mechanism of resveratrol on diabetes and diabetic complications

白藜芦醇是一种天然植物抗毒素,广泛存在于多种植物中。白藜芦醇对糖尿病及其并发症的药理作用机制多样,包括激活SIRT1和AMPK等增加胰岛素敏感性,改善胰岛素抵抗;激活Akt通路、增加GLUT2的表达以及抑制PDK,影响糖代谢进程降低血糖水平;激活SIRT1蛋白、PGC-1α蛋白以及参与线粒体途径,促进SOD1的生成、降低ROS的表达以及减少线粒体凋亡,减少胰岛β细胞的氧化应激损伤;也能通过激活AMPK通路、PPARα通路以及下调VEGF受体Flk-1的表达改善糖尿病肾病,抑制NF-κB而改善糖尿病性肝损伤和糖尿病视网膜病变等。综述了近5年来白藜芦醇对糖尿病及其并发症作用机制的研究进展,为进一步研究开发提供参考。

Resveratrol is a natural phytoalexin that exists widely in many plants.Resveratrol has a variety of mechanism of action on diabetes and its complications.Firstly,resveratrol activates SIRT1 and AMPK,increases insulin sensitivity and improves insulin resistance.Secondly,resveratrol activates the Akt pathway,increases the expression of GLUT2 and inhibits PDK,and affects the glucose metabolism process to reduce the blood glucose level.Resveratrol can activate SIRT1 protein and PGC-1α protein,and participate in mitochondrial pathway,promote SOD1 production,reduce ROS expression,reduce mitochondrial apoptosis and reduce oxidative stress damage of pancreatic β-cells.On the one hand,resveratrol can also improve the diabetic nephropathy by activating the AMPK pathway,PPARα pathway and down-regulating the expression of VEGF receptor Flk-1.In addition,resveratrol can inhibit NF-κB,improve diabetic liver injury and diabetic retinopathy.In this paper,the progress of resveratrol on the mechanism of diabetes and its complications in recent five years are reviewed to provide a reference for the further research and development of resveratrol.