高原老年肺炎患者感染病原菌分布及对患者Smad通路蛋白的调控

The Pathogen Distribution and its Effect on TGFβ-Smad Signaling Pathway Proteins in Patients with Elderly Pneumonia

目的本研究探讨高原老年肺炎患者感染病原菌分布情况及对患者Smad通路蛋白的调控。方法对229例高原老年肺炎患者进行研究,分析患者感染病原菌的分布情况及与患者Smad通路蛋白的调控作用。以同期高原健康体检者100例和老年肺炎未感染患者120例为对照。结果 229例老年肺炎感染患者中共分离病原菌229株,其中革兰阳性菌102株,占44.5%,革兰阴性菌101株,占44.1%,真菌26株,占11.4%;与正常组和老年肺炎未感染组患者相比,老年肺炎感染组患者血清中TGFβ-Smad通路蛋白、白细胞介素和TNFα、CRP、BNP、Cys C蛋白的表达明显增强,且与对照组相比差异有显著的统计学意义(P<0.05)。结论高原老年肺炎患者感染病原菌以细菌为主,且感染后明显增强TGFβ-Smad通路蛋白的表达。

Objective The present research aimed to analyze the pathogen distribution and its effect on TGFI3- Smad signaling pathway proteins in patients with elderly pneumonia. Methods 229 cases of patients with elderly pneumonia in our hospital from Jan 2010 to Nov 2015 were enrolled in this research.The distribution and location of the pathogens were identified by VITEK2 Compact equipment.The serum TGFβ-Smad signaling pathway proteins and interleukins combined CRP, CysC and BNP were detected by ELISA. 100 cases of healthy subjects and 120 ca- ses of patients with non-pathogen infected elderly pneumoniain our hospital were taken as control at the same time. Results The pathogens isolated from the patients included 102 strains （44.5%）of gram positive bacteria and 101 strains（44.1%） of gram negative bacteria.The serum TGFβ-Smad related proteins, CRP, ILl, IL2, ILl0, BNP, as well as CysC were decreased significantly in infected patients when compared with control（P〈0.05）.Conclusion Elderly pneumonia patients are suffered from pathogen infection and abnormal serum TGFβ-Smad related proteins are involved in this process.